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A Case of Periarteritis Nodosa of the Central Nervous System

Holloway Sanatorium, Virginia Water

Turner McLardy, M.B.E., B.Sc., D.P.M., Honorary Consultant Neuropathologist

Bethlem Royal and Maudsley Hospital, London

Cyril Harris, M.B., D.P.M., Consultant Psychiatrist

Holloway Sanatorium, Virginia Water

ABSTRACT

The clinical and pathological findings are described in a fatal case of periarteritis nodosa confined largely to the central nervous system and associated throughout the last year of life with conspicuous mental symptoms. The diffuse, variable, intermitting, almost purely neurological signs and symptoms defied correct clinical diagnosis throughout an illness of two years' duration. The cerebrospinal fluid displayed an abnormal amount of total proteins, increased lymphocytes and a low luetic type of colloidal gold curve. A striking remission in the physical, serological and mental state of the patient coincided with a two months' course of pyretotherapy by means of T.A.B. vaccine, whereas a very sudden relapse and progressive deterioration coincided with the occurrence of urticaria during a course of injections of neo-arsphenamine.