© 2008 The Royal College of Psychiatrists
Correspondence |
Author's reply
Liverpool University, Hollins Park Hospital, Warrington WA2 8WA. Email: esalib{at}hotmail.com
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
Jongbloet provides an alternative explanation of our findings about the effect of month of birth on suicide that is based on the oocyte origins hypothesis as opposed to the maternal–foetal origin hypothesis. The oocyte hypothesis (also referred to in literature as `conception hypothesis') may have significant implications in psychiatry. The intricate interplay between non-optimal oocyte maturation and genes results in a complex pathogenesis of the resultant foetuses or individuals. This occurs in well-timed menstrual cycles, but more so in instances of distorted hormonal tuning, not only in deprived socio-economic conditions but also at the extremes of maternal reproductive life, among endocrinologically unbalanced mothers, after very short pregnancy intervals during the seasonal transitions of the `ovulatory' seasons, etc.1 A similar broad spectrum of male-biased developmental anomalies – low birth weight and length, small stature at school age or adulthood, morbidity, and mortality – is present in all these circumstances.2
To illustrate the oocyte or conception hypothesis in practical terms: mothers with low socio-economic status are known to suffer from more menstrual disorders,3 low standards of nutrition and abnormal body mass index. They also are more likely to be smokers or to misuse drugs4 and to employ less safe methods of contraception resulting in unplanned and unwanted pregnancies, particularly at the extremes of maternal reproductive age and during the postpartum restoration of the ovulatory pattern (i.e. after very short inter-pregnancy intervals). They are likely to have non-optimal oocyte maturation, thus rendering the offspring vulnerable to low birth weight and certain psychiatric disorders. However, we are not clear as to how this hypothesis actually differs from the maternal–foetal origin hypothesis used to explain our findings.5
The geographical latitude effect in incidence rates of suicide in England, Wales and elsewhere is assumed by Jongbloet to be a consequence of the stronger seasonal ovulatory pattern the further away from the equator, just as in animals, and, in turn, stronger transitional stages between the ovulatory seasons and, thus, more poor-quality oocytes. However, the only way to accept or reject this concept is by demonstrating the same increase of suicide incidence rate – and of other disease entities or behaviour of complex origin.
We are also grateful to Chotai for his comments. Although we did not look at hanging in relation to month of birth in our study, we did in fact examine the relationship between month of birth and violent suicide (including hanging) as opposed no non-violent suicide, but found no significant association. However, a previous study,6 in an attempt to replicate the findings of Chotai et al,7 showed that those born during the season January–April were more likely to prefer hanging than poisoning: data from North Cheshire (n=502) appeared to suggest that suicide by hanging was significantly more frequent in those born in the summer months compared with those who used other methods such as poisoning by solids or gases. The findings were not in keeping with reports by Chotai et al. However, methodological limitations of the North Cheshire study, including a relatively small sample size, have significantly limited its inferential value. Studies with sufficient power to detect the association between month of birth and risk of hanging are required to show whether one truly exists. Seasonality of birth studies in relation to suicide may enhance our understanding of some biological aspects in the aetiology of suicide such as the oocyte origins hypothesis proposed by Jongbloet.
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- Chotai J, Salander Renberg E, Jacobsson L. Season of birth associated with the age and method of suicide. Arch Suicide Res 1999; 5: 245 -54.
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