© 2008 The Royal College of Psychiatrists
Highlights of this issue
Obstetric events and mental disorder
Fergusson et al (pp. 444–451) conducted an analysis of longitudinal data from the Christchurch Health and Development Study in order to examine the links between pregnancy and mental health outcomes. The authors comment that this is an area of research which has been beset by inconsistent findings, methodologically flawed studies, and ideologically driven researchers. Induced abortion was found to be associated with a small increase in risk of mental disorder but other pregnancy outcomes were not related to risk of mental health problems. In an Australian study, Dingle et al (pp. 455–460) compared psychiatric outcomes in women after induced abortion and miscarriage. In this birth cohort study, young women reporting a pregnancy loss, either abortion or miscarriage, had nearly three times the odds of a lifetime drug use disorder. Abortion was also associated with having an alcohol use disorder and 12-month depression.
Borderline personality disorder
In a Spanish study by Pascual et al (pp. 471–476), those being admitted to a psychiatric emergency service were found to be diagnosed with borderline personality disorder less frequently if they were of immigrant compared with indigenous background. Particularly low rates of diagnosis were found among those of Asian and sub-Saharan African origin. Two papers in the Journal this month describe interventions for borderline personality disorder. Chanen et al (pp. 477–484) report on a randomised controlled trial (RCT) to investigate the effectiveness of cognitive analytic therapy (CAT) compared with manualised good clinical care for out-patients aged 15–18 years. Both interventions were equally effective in reducing externalising symptomatology and no adverse effects were detected for either. There was some evidence of more rapid improvement among those receiving CAT. Schulz et al (pp. 485–492) report on a large multicentre RCT designed to assess the efficacy of variable-dosed olanzapine v. placebo for adult out-patients with borderline personality disorder. Both trial arms showed improvements and did not differ at the end-point. Time to response was, however, significantly shorter for those receiving olanzapine but the occurrence of weight gain and elevated prolactin levels was higher.
Interventions for bereavement and bulimia nervosa
McDaid et al (pp. 438–443) conducted a systematic review of interventions for individuals bereaved through suicide. Eight controlled studies were identified and all but one had significant methodological flaws. Compared with no intervention, there was some evidence of benefit for specific interventions from single studies whereas studies that included two or more active interventions were more equivocal. Schmidt et al (pp. 493–500) report findings from an RCT designed to assess the effectiveness of a CD–ROM-based cognitive–behavioural self-care intervention for individuals with bulimia nervosa and eating disorders not otherwise specified. The study was conducted in a routine setting and individuals were randomised to either CD–ROM without support for 3 months or waiting list, with both receiving therapist-delivered cognitive–behavioural therapy after this period. Although the CD–ROM group appeared to do better at the 3-month point, the opposite appeared to be true at 7 months, and on post hoc analysis no differences were found at either time point.
IQ and risk of death from homicide
In a large cohort of Swedish men administered an IQ test at military conscription, mortality was examined over a 20-year period (Batty et al, pp. 461–465). A high IQ score was found to be associated with a reduced risk of death from homicide, with a gradient seen across IQ groups. The association was reduced by only a small amount after adjustment for confounders.
Cornelia de Lange syndrome
Abnormalities on chromosomes 5, 10 and X have been found to be associated with Cornelia de Lange syndrome – characterised by a physical phenotype, intellectual disability, poor expressive communication and self-injurious behaviour. In a case–control study by Oliver et al (pp. 466–470), the behavioural phenotype of the syndrome was explored. No differences were found on global measures of behavioural disorder when those with the syndrome were compared with a control group with intellectual disability, but severe autism was more common in the syndrome group. Higher levels of compulsive behaviour were also found.
Related articles in BJP:
- Interventions for people bereaved through suicide: systematic review
- Catriona McDaid, Rebecca Trowman, Su Golder, Keith Hawton, and Amanda Sowden
BJP 2008 193: 438-443.[Abstract] [Full Text] - Abortion and mental health disorders: evidence from a 30-year longitudinal study
- David M. Fergusson, L. John Horwood, and Joseph M. Boden
BJP 2008 193: 444-451.[Abstract] [Full Text] - Pregnancy loss and psychiatric disorders in young women: an Australian birth cohort study
- Kaeleen Dingle, Rosa Alati, Alexandra Clavarino, Jake M. Najman, and Gail M. Williams
BJP 2008 193: 455-460.[Abstract] [Full Text] - IQ in early adulthood and later risk of death by homicide: cohort study of 1 million men
- G. David Batty, Ian J. Deary, Anders Tengstrom, and Finn Rasmussen
BJP 2008 193: 461-465.[Abstract] [Full Text] - Behavioural phenotype of Cornelia de Lange syndrome: case–control study
- Chris Oliver, Kate Arron, Jenny Sloneem, and Scott Hall
BJP 2008 193: 466-470.[Abstract] [Full Text] - Immigrants and borderline personality disorder at a psychiatric emergency service
- J. C. Pascual, A. Malagón, D. Córcoles, J. M. Ginés, J. Soler, C. García-Ribera, V. Pérez, and A. Bulbena
BJP 2008 193: 471-476.[Abstract] [Full Text] - Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: randomised controlled trial
- Andrew M. Chanen, Henry J. Jackson, Louise K. McCutcheon, Martina Jovev, Paul Dudgeon, Hok Pan Yuen, Dominic Germano, Helen Nistico, Emma McDougall, Caroline Weinstein, Verity Clarkson, and Patrick D. McGorry
BJP 2008 193: 477-484.[Abstract] [Full Text] - Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study
- S. Charles Schulz, Mary C. Zanarini, Anthony Bateman, Martin Bohus, Holland C. Detke, Quynh Trzaskoma, Yoko Tanaka, Daniel Lin, Walter Deberdt, and Sara Corya
BJP 2008 193: 485-492.[Abstract] [Full Text] - Randomised controlled trial of CD–ROM-based cognitive–behavioural self-care for bulimia nervosa
- U. Schmidt, M. Andiappan, M. Grover, S. Robinson, S. Perkins, O. Dugmore, J. Treasure, S. Landau, I. Eisler, and C. Williams
BJP 2008 193: 493-500.[Abstract] [Full Text]
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