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PAPERS:
J. BURNS, D. JOB, M. E. BASTIN, H. WHALLEY, T. MACGILLIVRAY, E. C. JOHNSTONE, and S M. LAWRIE
Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
The British Journal of Psychiatry 2003; 182: 439-443 [Abstract] [Full text] [PDF]
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[Read eLetter] Structural Disconnectivity in Schizophrenia
Tejraj Tawde   (18 May 2003)

Structural Disconnectivity in Schizophrenia 18 May 2003
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Tejraj Tawde,
SHO
Newcastle General Hospital

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Re: Structural Disconnectivity in Schizophrenia

tejrajtawde{at}rediffmail.com Tejraj Tawde

The article, taking us closer and closer to the neurobiological origin of schizophrenia, is indeed very interesting.

The thought that instinctively comes to mind is about the possibilitly to go even deeper to examine the subcortical structures, viz. the amigdala, caudate, putamen, thalamus and their connections, and look for disconnectivity. Further more, it also occurs to the mind, if the different sets of symptom profiles in Schizophrenia would have specific patterns of abnormalities in the neuronal network, which could be identified in a similar manner.

Finally, could we estimate as to how soon would these findings be applicable at the clinical level.