eLetters published in the past 30 days:

Read letters published in the past 30, 60, 90, 120, 150, 180 days.

To submit a letter to the editor unrelated to a published article, click here

For a listing of all online letters to the Editor unrelated to published articles go to http://bjp.rcpsych.org/cgi/eletters/190/1/81-a

11 eLetters published for 8 different topic sources.

Articles    Letters
Jump to eLetters for citation
EDITORIALS:
The moral content of psychiatric treatment
Pearce and Pickard (1 October 2009) [Abstract] [Full text] [PDF]
Jump to eLetter Re: Setting limits to moral content in psychiatry
Steve Pearce, et al.   (10 November 2009)
Jump to eLetter Psychiatry as a moral science.
Alison J Gray, et al.   (28 October 2009)
Jump to eLetter Psychiatry, happiness and virtue
Liliya T. Bakiyeva   (28 October 2009)
 Read every eLetter to this article

Jump to eLetters for citation
PAPERS:
Structure of genetic and environmental risk factors for dimensional representations of DSM–IV anxiety disorders
Tambs et al. (1 October 2009) [Abstract] [Full text] [PDF]
Jump to eLetter Subthreshold symptoms: Can they be ignored?
Keertish N, et al.   (10 November 2009)
 Read every eLetter to this article

Jump to eLetters for citation
PAPERS:
Social anxiety disorder in first-episode psychosis: incidence, phenomenology and relationship with paranoia
Michail and Birchwood (1 September 2009) [Abstract] [Full text] [PDF]
Jump to eLetter Comorbid Social Anxiety in Psychosis ˇV Or Could it be Residual Ideas of Reference?
Gloria HY Wong, et al.   (23 November 2009)
 Read every eLetter to this article

Jump to eLetters for citation
PAPERS:
Rural–urban migration and depression in ageing family members left behind
Abas et al. (1 July 2009) [Abstract] [Full text] [PDF]
Jump to eLetter Migration: accepted when expected
Keertish N, et al.   (10 November 2009)
 Read every eLetter to this article

Jump to eLetters for citation
SHORT REPORTS:
Randomised evaluation of assertive community treatment: 3-year outcomes
Killaspy et al. (1 July 2009) [Abstract] [Full text] [PDF]
Jump to eLetter Active outreach
David H Yates   (28 October 2009)
 Read every eLetter to this article

Jump to eLetters for citation
SHORT REPORTS:
Lithium levels in drinking water and risk of suicide
Ohgami et al. (1 May 2009) [Abstract] [Full text] [PDF]
Jump to eLetter Reply to Drs Huthwaite and Stanley
Takeshi Terao, et al.   (10 November 2009)
 Read every eLetter to this article

Jump to eLetters for citation
PAPERS:
Reasons for discontinuing clozapine: matched, case–control comparison with risperidone long-acting injection
Taylor et al. (1 February 2009) [Abstract] [Full text] [PDF]
Jump to eLetter Response to Drs Preeti Parakh, Ashutosh Kumar, Gauri Shankar, Madhvi Rughoo, Ashish Nair and Abhishe
David M Taylor   (10 November 2009)
Jump to eLetter Clozapine: A Whipping Boy!
Preeti Parakh, et al.   (28 October 2009)
 Read every eLetter to this article

Jump to eLetters for citation
Correspondence:
Letters to the Editor
(1 January 2007) [Full text] [PDF]
Jump to eLetter Empathic skills of authors
Martin P Lock   (23 November 2009)
 Read every eLetter to this article
EDITORIALS:
The moral content of psychiatric treatment
Pearce and Pickard (1 October 2009) [Abstract] [Full text] [PDF]
The moral content of psychiatric treatment
Re: Setting limits to moral content in psychiatry
10 November 2009
 Next eLetter Top
Steve Pearce,
Consultant Psychiatrist
Oxfordshire and Buckinghamshire Mental Health NHS Foundation Trust,
Hanna Pickard

Send letter to journal:
Re: Re: Setting limits to moral content in psychiatry

steve.pearce{at}obmh.nhs.uk Steve Pearce, et al.

Virtue and the good of the patient

We want to thank Gray and Cox (1) and Bakiyeva (2) for their positive contributions to the position we develop in our article (3). We are also grateful to Foreman (4) for his critical analysis, which gives us the opportunity to further clarify our position.

Foreman is correct that no one would assert that being a mafia don is symptomatic of a mental disorder. But, as Bakiyeva points out, some of the psychological traits that may be present in such a person are constituents of mental disorders, even if they do not on their own justify diagnosis, e.g., aggression, callousness, lack of empathy or lack of remorse. By treating these traits, psychiatrists thus both improve the mental health of the patient and increase their capacity for virtue. Of course, Foreman is right that we can imagine a case where effective treatment, say, for impulse control, can be put by a person to immoral ends: the mafia don may choose to become more calculating in his cruelty. But that does not affect the basic point of our article, which is that there is a range of psychiatric symptoms which in themselves constitute or are typically associated with failures of virtue, and whose treatment therefore involves the development of moral skills in the patient.

Foreman is also correct that psychiatry’s primary concern is the good of the patient. But, as Aristotle said, man is a social animal: for many patients, it is not possible to lead a good life without healthy, meaningful social relationships and functioning. Virtue facilitates this. Effective treatment of the patient will benefit their relationships and functioning in society as a whole. That is good for the patient. In many cases, there may also be a derivative good for society. But that is not itself the aim of psychiatry. Recognizing the moral content of psychiatric treatment does not alter the fundamental point that our first duty is to our patients. We thus agree entirely with Foreman that psychiatrists should not participate in social interrogation. But we do not accept that our position invites them to.

1. Gray AJ, Cox J. Psychiatry as a moral science. (e- response, published online, Br J Psychiatry on 28 October 2009)

2 Bakiyeva LT. Psychiatry, happiness and virtue. (e- response, published online, Br J Psychiatry on 28 October 2009)

3. Pearce S, Pickard H. The moral content of psychiatric treatment. Br J Psychiatry 2009; 195: 281-2.

4. Foreman, D. Setting limits to moral content in psychiatry (e-response, published online, Br J Psychiatry on 22 October 2009)

Declaration of interest: none.

The moral content of psychiatric treatment
Psychiatry as a moral science.
28 October 2009
Previous eLetter Next eLetter Top
Alison J Gray,
Consultant Psychiatrist
University of Birmingham, School of Psychology, Edgbaston, Birmingham, B13 8DL, UK.,
John Cox

Send letter to journal:
Re: Psychiatry as a moral science.

graya{at}bham.ac.uk Alison J Gray, et al.

We agree with Pearce & Pickard that psychiatry is a moral value- laden medical science and we applaud their call for psychiatry to acknowledge that all medical practice has to do with promoting human flourishing and helping people to optimise their quality of life.

In other areas of medicine, for example orthopaedics, it is usually easy to see what promotes flourishing, a fractured hip is self-evidently a bad thing and needs replacement. However in psychiatry the right course of action may be much more difficult to see; for example a patients marriage is struggling and they are attracted to a new partner. Should they stay in the marriage or move on; should they prioritize fidelity and commitment or self-fulfillment?

Although psychiatrists are unlikely to give direct advice about the right course of action, they will form an opinion of what is right and this will influence what they say and what questions they ask next; the patient will know if their doctor approves or not.

‘How then should we live?’ is one of the fundamental questions, which we all have to consider and form our own values. Being aware of our values will help to prevent conflict with service users who may hold different values and assumptions about the world (1).

Virtue ethics gives a useful structure for considering what is right, there has been considerable development in this area since Aristotle(2). The virtue of Compassion is currently being focused on by many spiritual leaders as a universal human value and is regarded as a core professional attribute (3).

The traditional religions also have many resources and spiritual practices which can help in the development of the virtues, help answer the question ‘How then should we live?’ and to give the motivation and power to live more virtuous lives.

In DH consultation paper ‘New Horizons’ (4) mental health professionals are urged to consider these existential issues such as ‘meaning and purpose’-as well as promoting ‘well –being’. Assistance from Moral philosophy, ethical reasoning and comparative religion may therefore facilitate this key CPD agenda - and is particularly pertinent for post- modern contemporary psychiatrists working in multi faith communities.

1. Woodbridge K, Fulford B. Whose value? A workbook for values-based practice in mental healthcare. London: Sainsbury Centre for Mental Health; 2004

2. MacIntyre A. After Virtue: a study in moral theory Duckworth 3rd Edn (revised) 2007.

3. http://charterforcompassion.org/ last accessed 17.10.09

4. http://www.dh.gov.uk/en/Healthcare/Mentalhealth/NewHorizons/index.htm last accessed 17.10.09

360 words

Alison J Gray, University of Birmingham, School of Psychology, Edgbaston, Birmingham, B13 8DL, UK. Email: graya@bham.ac.uk

John Cox, University of Keele, Institute of Psychiatry, London, and University of Gloucestershire UK.

DOI: Alison Gray is a consultant psychiatrist, in training to be an ordained Anglican minister. John Cox, no interest to declare.

The moral content of psychiatric treatment
Psychiatry, happiness and virtue
28 October 2009
Previous eLetter Next eLetter Top
Liliya T. Bakiyeva,
Psychiatric Core Trainee
Oxford School of Psychiatry

Send letter to journal:
Re: Psychiatry, happiness and virtue

liliya.bakiyeva{at}gmail.com Liliya T. Bakiyeva

I would like to thank Pearce and Pickard for their edifying and thought-provoking editorial on the moral content of psychiatry (1). The authors state that "psychological interventions can lead to the acquisition and development of moral motives, skills and understanding", and therefore that the proper concern of psychiatry should be "helping patients to be more virtuous".

The first, instinctive, reaction that the editorial will elicit in the reader is likely to be one of doubt and dismissal. The authors address these feelings in their succinct analysis of the possible reasons for our failure to acknowledge the moral underpinnings of our specialty: the historical perspective and the moral relativity. Another possible reason is purely semantic. The authors' premise is that virtue is necessary for happiness (eudaemonia). Yet, if we substitute "happy" for "virtuous" to argue that "the proper concern of psychiatry should be helping patients to be more happy", we would somehow feel more at ease. This is interesting, since the word "happiness" is as value-laden as the word "virtue", and may be no less controversial. For example, a man may be happy molesting his young daughter, or a young boy may be happy torturing and killing pet animals. We would agree that it is our professional duty to help these patients to be more virtuous, even if being virtuous is incompatible with their immediate subjective happiness. Furthermore, it could be argued that, while limiting these patients immediate subjective happiness, we work towards increasing their ultimate potential for eudaemonia, by helping them to reduce or eliminate their maladaptive behaviours. Perhaps, a balance could be stricken by stating that "the proper concern of psychiatry should be helping patients to achieve personal (i.e., subjective) happiness while guided by objective virtues".

David Foreman (2) expresses his concerns with Pearce and Pickard's views and illustrates his point with a reconstruction of the authors' vignette. In his scenario, a recovering alcoholic becomes a Mafia don. I do not have enough practical experience in psychiatry to form an opinion on the likelihood of such an event taking place, given the deleterious consequences of heavy alcohol misuse on the person's cognitive abilities and organization skills, and I believe that is not the key issue in the discussion. There may not be a diagnostic category corresponding to "Mafia don" in either ICD-10 or DSM-IV, but the personality traits common in gangsters of any type, such as callousness, lack of empathy, aggression, impulsivity disregard to and violation of others' rights are certainly terms used in both classification systems as diagnostic criteria for personality disorders. If we could only administer SCID-II to the Godfather, I am sure we would have ended up with a formal diagnosis!

The issue of moral content of psychiatry is a very important - and a rather neglected one. I thank Pearce and Pickard for bringing the issue forth for debate.

Potential conflict of interests: I am trainee within the same Trust that employs one of the authors of the editorial (S.Pearce).

References: 1. Pearce S, Pickard H. The moral content of psychiatric treatment. Br.J.Psychiatry 2009; 195: 281-2. 2. Foreman, D. Setting limits to moral content in psychiatry (e-response, published online, British Journal of Psychiatry on 22 October 2009)

PAPERS:
Structure of genetic and environmental risk factors for dimensional representations of DSM–IV anxiety disorders
Tambs et al. (1 October 2009) [Abstract] [Full text] [PDF]
Structure of genetic and environmental risk factors for dimensional representations...
Subthreshold symptoms: Can they be ignored?
10 November 2009
Previous eLetter Next eLetter Top
Keertish N,
Resident of Psychiatry
Banaras Hindu University, Varanasi, India,
Ashish Nair

Send letter to journal:
Re: Subthreshold symptoms: Can they be ignored?

keerthish_shetty{at}rediffmail.com Keertish N, et al.

Dear editor,

The findings in this study seem to support the spectrum concept of anxiety disorders in which the dimensional approach takes precedence over the categorical approach. However, I fail to understand why subthreshold symptoms were not considered in an otherwise well designed study. There is clear evidence that the subthreshold anxiety disorders are more prevalent than the full-syndrome disorders[1]. Also, co-morbidity with other disorders is well documented even in those with subthreshold anxiety disorders[2]. This raises the question as to whether subthreshold symptoms and co-morbid conditions can be ignored if we are to reach a proper conclusion. Potential treatment implications of such studies necessitates further research.

References:

1. Carter RM, Wittchen HU, Pfister H, Kessler RC. One-year prevalence of subthreshold and threshold DSM-IV generalized anxiety disorder in a nationally representative sample. Depress Anxiety. 2001;13(2):78-88.

2. Lewinsohn PM, Shankman SA, Gau JM, Klein DN. The prevalence and co -morbidity of subthreshold psychiatric conditions. Psychol Med. 2004 May;34(4):613-22.

PAPERS:
Social anxiety disorder in first-episode psychosis: incidence, phenomenology and relationship with paranoia
Michail and Birchwood (1 September 2009) [Abstract] [Full text] [PDF]
Social anxiety disorder in first-episode psychosis: incidence, phenomenology and...
Comorbid Social Anxiety in Psychosis ˇV Or Could it be Residual Ideas of Reference?
23 November 2009
Previous eLetter Next eLetter Top
Gloria HY Wong,
PhD candidate
Department of Psychiatry, The University of Hong Kong,
Eric YH Chen

Send letter to journal:
Re: Comorbid Social Anxiety in Psychosis ˇV Or Could it be Residual Ideas of Reference?

gloriawong{at}hkusua.hku.hk Gloria HY Wong, et al.

Dear Editor,

We read with interest Michail and Birchwood's work on social anxiety disorder in psychosis.

Comorbidity is an important area of work in psychosis. Apart from the clinical implications, it provides clues to the pathological mechanisms underpinning psychosis. This may particularly be the case for social anxiety, which has been noted as a candidate endophenotype for psychosis.[1]

As such, it is all the more important that we get a true picture of its prevalence and relationship with psychosis. Taking into account the 13.3% lifetime prevalence of social anxiety disorder in the normal population,[2] current data do seem to suggest an excess in psychosis, although a wide range of prevalence between 17%[3] and 36.3%[4] in outpatients have been reported. Results to-date have also been confusing about the relationship between social anxiety and schizophrenic symptoms, with studies pointing to all kinds of directions as to the association with positive symptoms, negative symptoms, or both, or neither.

Should these bewildering data be telling us anything at all, it is that there may be something elusive in the way social anxiety presents itself in psychosis that hinders reliable capturing of it. Insightful researchers such as Michail et al have already started to suspect a possible overlap with paranoia. While their study did not find any conclusive relationship between social anxiety and persecutory delusions, we propose that the other component within the paranoia construct, namely ideas of reference (IOR), may be the real target that has been overlooked in previous studies.

Social anxiety and IOR are close to each other conceptually and in their presentations. Both are prodromal signs and schizotypal features, and may manifest as increased self-consciousness, fear and avoidance in certain social situations, with the subjects being aware of the excessive nature of such feelings. More subtle differences between the two may be noticed with more careful questioning (eg, IOR seldom involves anticipation anxiety), it is doubted whether existing scales or diagnostic instruments have enough sensitivity to tell them apart. Our group has some initial data that suggest many items on standard social anxiety assessments load heavily on IOR (manuscript in preparation).

This immediately raises an important question: to what extent is the 'comorbid social anxiety' phenomenon contaminated by residual IOR (or vice versa)? We know that IOR is common and can be found in up to 70% of patients,[5] and more importantly, it is a warning signal for impending relapse. The suggested management for comorbid social anxiety (eg, selective serotonin reuptake inhibitors, neuroleptics dose reduction or cognitive behavioural therapy) may be ineffective if not harmful if residual IOR is at its root.

At the moment, the very first thing we can do would be to develop psychopathologically refined, 'clean' tools to measure social anxiety in schizophrenia. This has been done for depression with the Calgary Depression Scale for Schizophrenia (CDSS), which excludes negative symptoms and antipsychotic side effects as confounders. It is only after the potential contamination by IOR is safely ruled out can we start to investigate with confidence comorbid social anxiety and its relationship with psychosis.

References: 1. Johnstone CE, Ebmeier KP, Miller P, Owens DGC, Lawrie SM. Predicting schizophrenia: findings from the Edinburgh High-Risk Study. Br J Psychiatry 2005; 186: 18ˇV25. 2. Lang AJ, Stein MB. Social phobia: Prevalence and diagnostic threshold. J Clin Psychiatry 2001;62(suppl 1):5-10. 3. Braga RJ, Mendlowicz MV, Marrocos RP, Figueira IL. Anxiety disorders in outpatients with schizophrenia: Prevalence and impact on the subjective quality of life. J Psychiatr Res 2005;39:409-414. 4. Pallanti S, Quercioli L, Hollander E. Social anxiety in outpatients with schizophrenia: a relevant cause of disability. Am J Psychiatry 2004;161:53-58. 5. World Health Organization. Schizophrenia: A Multinational Study. World Health Organization, Geneva; 1975.

Declaration of interest: none.

PAPERS:
Rural–urban migration and depression in ageing family members left behind
Abas et al. (1 July 2009) [Abstract] [Full text] [PDF]
Rural–urban migration and depression in ageing family members left behind
Migration: accepted when expected
10 November 2009
Previous eLetter Next eLetter Top
Keertish N,
Resident of Psychiatry
Banaras Hindu University, Varanasi, India,
Ashish Nair

Send letter to journal:
Re: Migration: accepted when expected

Keerthish_shetty{at}rediffmail.com Keertish N, et al.

Dear editor,

This article is of great relevance especially in developing countries. Most of the people live in closely knit families which ensures that emotional demands are met even in absence of the earning member. Thus, financial demands take the top priority. Some families also take great pride in sending their wards to work in defence forces. Migration also gives other options to those family members who are unwilling to carry out family professions. Therefore, it would have been interesting if the study had considered these factors also, because migration is more likely to be accepted when it is expected.

SHORT REPORTS:
Randomised evaluation of assertive community treatment: 3-year outcomes
Killaspy et al. (1 July 2009) [Abstract] [Full text] [PDF]
Randomised evaluation of assertive community treatment: 3-year outcomes
Active outreach
28 October 2009
Previous eLetter Next eLetter Top
David H Yates,
Retired Psychiatrist
Family carer

Send letter to journal:
Re: Active outreach

davidmet{at}ticali.co.uk David H Yates

Your letter about Assertive outreach [ I prefer Active outreach, it's more peaceful and is easier to see that often it is inactive ] having to go further for subsequent recovery, going on with keeping contact and providing a Recovery programme of activities, is very pertinent.

It resonates with the alarm at the unexpected and unsettling rise in the rate of homicides down to schizophrenia.

A problem in providing and delivering this aftercare for schizophrenai is that most with schizophrenia will not meet the current preference in funding agencies for getting people back into fulltime work. Those with residual schizophrenia do still need to have a programe in the week which mediates for them, at their level of experience and educaton, a regular routine of some activity in the week ahead, - training, education, interest pursuits, which hold them onto outside engagement and into some approriate company. The National Service Farmework [NSF}standards end this month. The service to the other serious and enduring mental illnesses have much improved. It may be that in some replacment statement they should lose the priority that the NSF afforded to them hitherto.

But there is no such improvement in service to schizophrenia. It should remain as the unfinished priority for commissioning and delivery. The national service to the illness must receive a more prominent oversight, and awaits an ovedue urgent and continuing review from the National Director and the Royal College

D H Yates FRC Psych family carer

SHORT REPORTS:
Lithium levels in drinking water and risk of suicide
Ohgami et al. (1 May 2009) [Abstract] [Full text] [PDF]
Lithium levels in drinking water and risk of suicide
Reply to Drs Huthwaite and Stanley
10 November 2009
Previous eLetter Next eLetter Top
Takeshi Terao,
Professor
Oita University Faculty of Medicine,
Hirochika Ohgami, Ippei Shiotsuki, Nobuyoshi Ishii, Oita University Faculty of Medicine, Noboru Iwata, Hiroshima International University

Send letter to journal:
Re: Reply to Drs Huthwaite and Stanley

terao{at}med.oita-u.ac.jp Takeshi Terao, et al.

We thank Drs Huthwaite and Stanley for their letter to our short report (1) and would like to reply as follows.

1) They pointed out that a major concern is the likelihood of confounding in this scenario.

In our previous research (2), we examined government statistics on suicide of the 47 prefectures in Japan. The overall yearly suicide rate in Japan was 25 per 100,000 population in 1999. Pearson's correlation was used to calculate correlations of suicide rate with latitude, longitude, yearly mean temperature, yearly total sunshine, yearly mean individual income, and yearly unemployment rate in the 47 prefectures, although lithium levels were not measured in the study. There was a significant correlation with suicide rate for yearly total sunshine, yearly mean temperature, latitude, and yearly mean individual income. By using multiple regression analysis, yearly total sunshine was the only individual variable to predict significant variance in suicide rate. Taking these findings into consideration, we did not use yearly mean individual income or yearly unemployment rate (1). Also, yearly total sunshine was similar between the 18 municipalities of Oita prefecture and we did not use this. Most importantly, only 18 municipalities prevented us from further analyses including confounding factors. We are now planning to perform a large study to consider confounding factors.

2) They stated that the potential reasons behind difference in lithium levels in the drinking water samples in the different municipalities are also not explained and asked how valid it is then to use the mean value to represent the lithium exposure in that area.

Lithium levels of drinking water supplier were measured at 26 locations in Oita city and at 53 locations in the other municipalities. The reason for the large difference in lithium levels is unknown, but Oita prefecture may have different geological features between the 18 municipalities and such difference may bring about large difference in lithium levels although this thought is speculative. Also, instead of the mean value, we used the median value for the analysis and the similar results were obtained.

3) They asked the duration of exposure to a specific level of lithium in the drinking water and where people source most of their drinking water and the use of bottled water.

In Japan, most people drink tap water although a small portion of people drink bottled water. Therefore, it is meaningful to measure lithium levels in tap water supplier. Moreover, the duration of exposure to a specific level of lithium is unknown but if the residents continue to live at the same place, then their age may be associated with the duration.

4) They said that in the context of the short report it is also difficult to fully assess the suitability of the analysis methods used.

We agree with them. Nonetheless, we believe that short report itself is not conclusive but can provide new findings which leads to comprehensive research to establish a definite conclusion. We would like readers to read a short report as such, which can prevent misleading.

Declaration of Interest: None

1. Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N. Lithium levels in drinking water and risk of suicide. Br J Psychiatry 2009; 194: 464-5.

2. Terao T, Soeda S, Yoshimura R, Nakamura J, Iwata N. Effect of latitude on suicide rates in Japan. Lancet 2002; 360: 1892.

PAPERS:
Reasons for discontinuing clozapine: matched, case–control comparison with risperidone long-acting injection
Taylor et al. (1 February 2009) [Abstract] [Full text] [PDF]
Reasons for discontinuing clozapine: matched, case–control comparison with risperidone...
Response to Drs Preeti Parakh, Ashutosh Kumar, Gauri Shankar, Madhvi Rughoo, Ashish Nair and Abhishe
10 November 2009
Previous eLetter Next eLetter Top
David M Taylor,
Chief Pharmacist
Maudsley Hospital

Send letter to journal:
Re: Response to Drs Preeti Parakh, Ashutosh Kumar, Gauri Shankar, Madhvi Rughoo, Ashish Nair and Abhishe

david.taylor{at}slam.nhs.uk David M Taylor

Almost all of the points raised by your correspondents are discussed in the original paper. Three additional points need addressing. First, I see no reason to exclude incidental findings from a study report simply because they were not included in the original aims of the study. Second, it is not far-fetched to conclude that people with schizophrenia treated with clozapine have a higher mortality than the general population. Every other study in this area has found exactly the same outcome. Indeed, mortality is higher in schizophrenia than in the general population in people receiving any antipsychotic (1). Third, I do not believe there is any bias against clozapine in the paper. We simply reported our findings.

1.Tiihonen J, Lonnqvist J, Wahlbeck K et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 2009;Epub ahead of print-DOI:10.1016/SO140- 6736(09)60742-X.

Reasons for discontinuing clozapine: matched, case–control comparison with risperidone...
Clozapine: A Whipping Boy!
28 October 2009
Previous eLetter Next eLetter Top
Preeti Parakh,
Junior Resident in Psychiatry
Institute of Medical Sciences, Banaras Hindu University, Varanasi, India,
Ashutosh Kumar, Gauri Shankar, Madhvi Rughoo, Ashish Nair and Abhishek Pathak

Send letter to journal:
Re: Clozapine: A Whipping Boy!

drpreeti9{at}yahoo.co.in Preeti Parakh, et al.

The article raised some queries in our minds. The authors state in the abstract that their aim is to compare the reasons for discontinuation of clozapine with that for risperidone long-acting injection. They, however, conclude that clozapine is associated with a significantly increased risk of death compared to that of the general population and that the common causes of clozapine discontinuation are death and adverse effects. Their conclusions not only seem unrelated to their stated aim but also are far-fetched considering their study design.

None of the mortalities in the clozapine group occurred due to an established adverse effect of clozapine and the deaths could very well have been due to a concurrent physical illness or due to the poor hygiene and nutritional status often found in chronic schizophrenics or even due to the cumulative adverse effects of all the drugs the patient had been on prior to starting clozapine. The authors themselves have acknowledged that their failure to collect information on concurrent medical illnesses, smoking status and duration of illness could have confounded the results. Moreover, since schizophrenics are known to have a higher risk of death from natural causes than the general population, ascribing a contributory role for clozapine in the deaths, without even attempting to assess the other factors that could have affected the outcome, is not only precipitous but also imprudent.

The patients who have to be put on clozapine are more likely to have a refractory illness than those on risperidone long-acting injection. Clozapine is also likely to have more disabling side-effects than long- acting risperidone. In spite of this, the clozapine group persisted longer (mean 12.3 months) with the treatment before discontinuation than the risperidone group (mean 5.9 months). This, in our opinion, is an important finding of the study, which has been ignored by the authors. This, along with the fact that the authors jumped the gun in attributing an increased mortality risk to clozapine, suggests a bias against clozapine.

Correspondence:
Letters to the Editor
(1 January 2007) [Full text] [PDF]
Letters to the Editor
Empathic skills of authors
23 November 2009
Previous eLetter  Top
Martin P Lock,
Consultant Forensic Psychiatrist
None

Send letter to journal:
Re: Empathic skills of authors

dr.martinlock{at}tiscali.co.uk Martin P Lock

At a recent Connecting Conversations event produced, by amongst others, the Institute of Psychoanalysis, the author Sebastian Faulks was interviewed by the psychoanalytic psychotherapist Monica Lanman. Mr Faulks said he was honoured to talk to such an audience, beleiving he was untrained. It appears to me that to be a really good author requires empathic skills at least as good as a psychiatrist's or psychoanalyst's. Mr Faulks has demonstrated his deep understanding of psychitry and psychoanalysis in Human Traces (1) and it is difficult to imagine a better description of a person with a schzoid personality disorder, and it potential forensic implications, than Engleby (2). Many authors have created illuminating characters with an array of psychiatric conditions. Agatha Christie (3) described a man with psychopathy 5 years before the publication in the USA of Cleckley's seminal work on the condition (4). Ms Christie's description of thallium poisoning, acquired whilst working in the pharmacy department of London's University College Hospital during World War Two, also was so accurate it enabled doctors to solve a number of mysterious cases (5). It is surely the depth of reading required to make one a really good psychiatrist that makes it so interesting.

(1) Sebastian Faulks. Human Traces. Hutchinson. 2005. (2) Sebastian Faulks. Engleby. Hutchinson. 2007. (3) Agatha Christie. The ABC Murders. Collins Crime Club. 1936. (4) Hervey Cleckley. The Mask of Sanity. St Louis, M.O.: C.V. Mosby. 1941. (5) Agatha Christie. The Pale Horse. Collins Crime Club. 1961.