Schizophrenia: A New Approach. II. Result of a Year's Research
Abram Hoffer, Humphrey Osmond, John Smythies


Using a hypothesis first published in this journal last year the authors and their colleagues of the Saskatchewan Schizophrenia Research Group have shown that adrenochrome, a derivative of adrenaline, has psychological properties similar to those of mescaline and lysergic acid. This is the first time that a substance which probably occurs in the human body has been found to be active in this way. Adrenochrome has also been shown to produce E.E.G. changes in normal and epileptic people and to inhibit the aerobic and anaerobic respiration of brain tissue in the Warburg apparatus. Future work in this field is discussed. Those who wish to work with adrenochrome are warned of certain dangers.


  • * Published with the approval of Saskatchewan Committee for Schizophrenia Research, c/o Psychiatric Services Branch, Dept. of Public Health, Regina, Saskatchewan.