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Intravenous Acetylcholine Therapy in Neurosis

A Controlled Clinical Trial

Published online by Cambridge University Press:  08 February 2018

J. R. Hawkings
Affiliation:
From the Midland Hospital for Nervous Diseases, United Birmingham Hospitals
R. W. Tibbetts
Affiliation:
From the Midland Hospital for Nervous Diseases, United Birmingham Hospitals

Extract

It is now several years since acetylcholine was first administered intramuscularly in the symptomatic treatment of anxiety, on the theory that anxiety was sympathicotonic in nature and could be counteracted by the vagotonic action of acetylcholine. Unfortunately decomposition of acetylcholine is so rapid that there is little time for this action to be effective, and the majority of investigators believe that it has no effect, or at least a momentary one, when given either subcutaneously or intramuscularly. Maxwell Jones (1936) used carbachol, a drug with a similar but more prolonged action than acetylcholine to treat six patients with anxiety neurosis. He was able to report relief from the psychic and somatic symptoms of anxiety in all cases but unfortunately, following withdrawal of the drug, they tended to relapse. An entirely different rationale led Tomasson (1936) to claim both alleviation and shortening of the duration of attacks of mania in manic depressive psychotics using a combined ephedrine and acetylcholine treatment.

Type
Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1956 

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References

Alexandre, H., and Almeida, VY. de Se, J. brasil, psiquiat., 1951, 1, 344.Google Scholar
Au, V., Cervello, 1940, 19, 121.Google Scholar
Borgarello, G., Schizofrenie (Supp.), 1939, 7, 83.Google Scholar
Cohen, L. H., Thale, N. J., and Tissenbaum, M. J., Arch. Neurol. Psychiat., 1944, 51, 171.CrossRefGoogle Scholar
Demetrio, F., Arch. Neuropsiq., S. Paulo, 1945, 3, 34.CrossRefGoogle Scholar
Ferrio, C., Allg. Z. Psychiat., 1942, 119, 268.Google Scholar
Fiamberti, A. M., G. Psichiat. Neuropat., 1939, 67, 270.Google Scholar
Idem , Méd. int., 1947, 55, 60.Google Scholar
Idem , Cong. Int. Psychiat. (Paris), 1950, 4, 70.Google Scholar
Harris, M. M., and Pacella, B. L., Arch. Neurol. Psychiat., 1943, 50, 304.CrossRefGoogle Scholar
Ibor, J. Lopez, Cong. Int. Psychiat. (Paris), 1950, 4, 85.Google Scholar
Jones, M. S., J. Ment. Sci., 1936, 82, 785.CrossRefGoogle Scholar
Kulcsar, I., and Lajtavari, L., Orv. Hétil., 1940, 84, 33.Google Scholar
Idem , Proc. R. Soc. Med., 1952, 45, 511.Google Scholar
Maclay, D. T., J. Ment. Sci., 1953, 99, 809.CrossRefGoogle Scholar
Phillips, R. M., and Hutchinson, J. T., Brit. med. J., 1954, i, 1468.CrossRefGoogle Scholar
Poort, R., and Stigaard, A., Nord. med., 1944, 21, 55.Google Scholar
Sacristan Hernandes de Tejada, J. M., Farmacoter. act., 1947, 4, 673.Google Scholar
Sandri, P., Cervello, 1940, 19, 67.Google Scholar
Sargant, W., Proc. R. Soc. Med., 1952, 45, 515.Google Scholar
Schaeffer, H., Pr. méd., 1947, 55, 505.Google Scholar
Sogliani, G., Rass. Studi psichiat., 1951, 40, 291.Google Scholar
Stigaard, A., Acta med. scand., 1944, 118, 313.CrossRefGoogle Scholar
Tibbetts, R. W., and Hawkings, J. R., J. Ment. Sci., 1956, 102, 60.CrossRefGoogle Scholar
Tomasson, H., J. Ment. Sci., 1936, 82, 595.CrossRefGoogle Scholar
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