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Placebos and their Psychological Effects

Published online by Cambridge University Press:  09 January 2018

Derrick S. Trouton*
Affiliation:
Institute of Psychiatry, Maudsley Hospital, London

Extract

Although numerous instances of the surprising efficacy of placebos in a wide variety of conditions have been reported lately, little has yet been done towards providing an explanation of the occurrence of placebo reactions in terms of psychology. In what follows, the main findings concerning placebos will first be described, and then an attempt made to relate them to psychological theory. Even if this attempt is premature, it may succeed in showing the need for further work and in suggesting what directions this might take.

Type
Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1957 

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References

Abramson, H. A., Jarvik, M. E., Kaufman, M. R., Kornetsky, C., Levine, A., and Wagner, M., “Lysergic acid diethylamide (LSD-25). I. Physiological and perceptual responses”, J. Psychol., 1955, 39, 360.Google Scholar
Abramson, H. A., Jarvik, M. E., Levine, A., Kaufman, M. R., and Hirsch, M. W., “Lysergic acid diethylamide (LSD-25). XV. The effects produced by substitution of a tap water placebo”, J. Psychol., 1955, 40, 367–83.Google Scholar
Baker, A. A., and Thorpe, J. G., “Placebo responses”, 1956. Typescript, 8 pp.Google Scholar
Baldwin, H. S. (see Cornell Conference), 1954.Google Scholar
Beecher, H. K., “Experimental pharmacology and measurement of the subjective response”, Science, 1952, 116, 157–62.Google Scholar
Idem , Keats, A. S., Mosteller, F., and Lasagna, L., “The effectiveness of oral analgesics (morphine, codeine, acetylsalicylic acid) and the problem of placebo ‘reactors' and ‘non-reactors’”, J. Pharmacol. exp. Ther., 1953, 109, 393400.Google Scholar
Idem , “The powerful placebo”, J. Amer. med. Ass., 1955, 159, No. 17, 24 December, 16021605.Google Scholar
Cabot, R. C., “The physician's responsibility for the nostrum evil”, J. Amer. med. Ass., 1906, 47, 982–3.Google Scholar
Cameron, W. M., and Kasanin, J., “A Pharmacologic and clinical re-evaluation of amphetamine sulphate (Benzedrine)”, New Engl. J. Med., 1941, 224, 544–50.CrossRefGoogle Scholar
Carter, A. B., “The Placebo. Its use and abuse”, Lancet, 17 October, 1953, ii, 823.Google Scholar
Cornell Conference on Therapy, , “How to evaluate a new drug”, Amer. J. Med., 1954, 17(5), 722–7.Google Scholar
Cronbach, L. J., “Statistical methods applied to Rorschach scores: a review”, Psychol. Bull., 1949, 46, 393429.Google Scholar
Diehl, H. S., Baker, A. B., and Cowan, D. W., “Cold vaccines: further evaluation”, J. Amer. med. Ass, 24 August, 1940, 115, 593–4.Google Scholar
Dorland, W. A. N., The American Illustrated Medical Dictionary, 1951, 22nd ed., pp. 1,736. Philadelphia and London: W. B. Saunders Co.Google Scholar
Eysenck, H. J., Dimensions of Personality, 1947, pp. 308. London: Routledge & Kegan Paul.Google Scholar
Idem , “A dynamic theory of anxiety and hysteria”, J. Ment. Sci., 1955, 101, 2851.Google Scholar
Idem , “The inheritance and nature of extraversion”, Eugenics Review, 1956a, 48, 2330.Google Scholar
Idem , “The inheritance of extraversion and introversion”, Acta Psychol., 1956b, 12, No. 2, 95110.Google Scholar
Fastier, F. N., “Effects of pentobarbitone, amphetamine and lactose on healthy students”, N.Z. med. J., 1955, 54, 74–9.Google Scholar
Felsinger, J. von, Lasagna, L., and Beecher, H. K., “Drug-induced mood changes in man. 2. Personality and reactions to drugs”, J. Amer. med. Ass, 26 March, 1955, 157, 1113–19.Google Scholar
Flory, C. D., and Gilbert, , “The effects of benzedrine sulphate and caffeine citrate on the efficiency of college students”, J. appl. Psychol., 1943, 27, 121–34.Google Scholar
Franks, C. M., “Conditioning and personality, a study of normal and neurotic subjects”, J. abn. soc. Psychol., 1956, 52, 143–50.Google Scholar
Gaddum, J. H., “Clinical pharmacology”, Proc. roy. Soc. Med., 1954, 47, No. 3, 195204.Google Scholar
Glaser, E. M., and Whittow, G. C., “Evidence for a non-specific mechanism of habituation”, J. Physiol., 1953a, 122, 43p44p.Google Scholar
Idem , “Experiments on the side-effects of drugs”, Brit. J. Pharmacol., 1953b, 8, 187–92.Google Scholar
Idem , and Whtttow, G. C., “Experimental errors in clinical trials”, Clin. Sci., 1954, 13(2), 199210.Google Scholar
Goodman, L., and Gilman, A., The Pharmacological Basis of Therapeutics, 1955, 2nd ed. New York: Macmillan Co.Google Scholar
Grace, W. J. (see Cornell Conference), 1954.Google Scholar
Grimes, F. V., “An experimental analysis of the nature of suggestibility and of its relation to other psychological factors”, Studies in Psychology and Psychiatry, 1948, 7, No. 4. Washington: Catholic University of America, pp. 44.Google Scholar
Hamilton, M., and Wilson, G. M., “The treatment of intermittent claudication”, Quart. J. Med., 1952, 21, 169–83.Google Scholar
Hampson, J. L., Rosenthal, D., and Frank, J. D., “A comparative study of the effects of mephenesin and placebo on the symptomatology of a mixed group of psychiatric outpatients”, Bull. Johns Hopkins Hosp., 1954, 95, 170–7.Google Scholar
Handheld-Jones, R. P. C., “A bottle of medicine from the doctor”, Lancet, 17 October, 1953, ii, 823–5.Google Scholar
Hawkings, J. R., and Tibbetts, R. W. J., “Intravenous acetylcholine therapy in neurosis. A controlled clinical trial”, J. Ment. Sci., 1956a, 102, 4351.CrossRefGoogle Scholar
Idem , “Carbon dioxide inhalation therapy in neurosis. A controlled clinical trial”, J. Ment. Sci., 1956b, 102, 52–9.Google Scholar
Hillis, B. R., “The assessment of cough suppressing drugs”, Lancet, 1952, i, 1230–5.Google Scholar
Jellinek, E. M., “Clinical tests on comparative effectiveness of analgesic drugs”, Biometrics Bull., 1946, 2, 8791.Google Scholar
Lasagna, L., Mosteller, F., von Felsinger, J. M., and Beecher, H. K., “A study of the placebo response”, Amer. J. Med., 1954, 16, 770–9.CrossRefGoogle Scholar
Idem , von Felsinger, J. M., and Beecher, H. K., “Drug-induced mood changes in man. 1. Observations on healthy students, chronically-ill patients and ‘postaddicts’”, J. Amer. med. Ass, 19 March, 1955, 157, 1006–20.Google Scholar
Idem , “Placebos”. Scientific American, August, 1955, 193, No. 2, 6871.Google Scholar
Leslie, A., “Ethics and practice of placebo therapy”, Amer. J. Med., 1954, 16, No. 6, 854–62.CrossRefGoogle Scholar
M.R.C. Special Committee Report, “Clinical trials of anti-histaminic drugs in the prevention and treatment of the common cold”, Brit. med. J., 1950, ii, 425–9.Google Scholar
Merry, J., “An experiment in a chronic psychotic ward”, Brit. J. med. Psychol., 1956, 29, 287–93.CrossRefGoogle Scholar
O'Brien, J. R., “Is liver a ‘tonic’? A short study of injecting placebos”, Brit. med. J., 1954, ii, 136–7.Google Scholar
Pinsent, E. J. F. H., “Discussion on medication in general practice”, Brit. med. J., 1951, ii, 1335–6, or Lancet, 1951, ii, 1068–9.Google Scholar
Rosenthal, D., and Frank, J. D., “Psychotherapy and the placebo effect”, Psychol. Bull., 1956, 53, 294302.Google Scholar
Steinberg, H., personal communication, 1956.Google Scholar
Straus, B., Eisenberg, J., and Gennis, J., “Hypnotic effects of an antihistamine—Methapyrilene hydrochloride”, Ann. intern. Med., 1955, 42, 574–82.Google Scholar
Tibbetts, R. W., and Hawkings, J. R., “The Placebo response”, J. Ment. Sci., 1956, 102, 60–6.Google Scholar
Tyler, D. B., “The influence of a placebo, body position and medication on motion sickness”, Amer. J. Physiol., 1946, 146, 458–66.Google Scholar
Idem , “The effect of amphetamine sulphate and some barbiturates on the fatigue produced by prolonged wakefulness”, Amer. J. Physiol., 1947, 150, 253–62.Google Scholar
Verplanck, W. S., “The control of the content of conversation: reinforcement of statements of opinion”, J. abnorm. soc. Psychol., 1955, 51, 668–76.Google Scholar
Wayne, E. J., “Placebos”, Brit. med. J., 21 July, 1956, ii, 157 (abstract).Google Scholar
Wolf, S., “Effects of suggestion and conditioning on the action of chemical agents in human subjects”, J. clin. Invest., 1950, 29, 100–9.Google Scholar
Idem , and Pinsky, R. H., “Effects of placebo administration and occurrence of toxic reactions”, J. Amer. med. Ass., 1954, 155, 339–41.Google Scholar
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