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Biochemistry and Schizophrenia

Published online by Cambridge University Press:  08 February 2018

Howard D. Fabing
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Extract

It is presumptuous for a clinician to embark on this subject, and I hasten to apologize for my boldness in doing so. My excuses are many. The first comes from clinical experience. Since my student days, when I observed malignant schizophrenia in a young girl for the first time, and watched its relentless progress despite all therapeutic efforts, I came to the belief that this was an illness of body as well as of mind, and this belief has led me to maintain a continuing interest in the medical, as distinct from the purely psychological, investigations of this disease throughout my professional years. Next has been the observation of experimental or model psychoses produced by drugs. An LSD or mescaline psychosis is not schizophrenia, any more than curare poisoning is myasthenia gravis, but there is enough similarity between the dissociation states produced by psychotomimetic drugs and the real thing to stimulate one's curiosity, at least.

Type
Anglo-American Symposium
Information
Journal of Mental Science , Volume 104 , Issue 435 , April 1958 , pp. 573 - 588
Copyright
Copyright © Royal College of Psychiatrists, 1958 

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References

Abood, L., Brain Research Inst. Conf., Chicago, Ill., 1957a. 12 January, p. 12.Google Scholar
Idem , “Biochemistry and Mental Illness”, 1957b. Read at Conf. on Biochemistry and Mental Illness, Univ. Brit. Col., Vancouver, B.C., 20 June, 1957.Google Scholar
Akerfeldt, S., Science, 1957a, 125, 117.Google Scholar
Idem , Brain Research Inst. Conf., Chicago, Ill., 1957b. 12 January, p. 7.Google Scholar
Idem , Read at 113th Meeting, A.P.A., Chicago, Ill., 1957c.Google Scholar
Altschule, M. D., Siegel, E. P., and Henneman, D. H., Arch. Neur. and Psych., 1952, 67, 64.CrossRefGoogle Scholar
Bleuler, E., Dementia Praecox or the Group of Schizophrenias, 1911. English translation (1950) by Zinkin, J. New York: Internat. Press.Google Scholar
Brodie, B. B., Tomich, E. G., Kuntzman, R., and Shore, P. A., J. Pharmacol. and Exper. Therap., 1957, 119, 481.Google Scholar
Dalgliesh, C. E., J. Clin. Path., 1955, 8, 73.Google Scholar
Erspamer, V., Pharmacol. Rev., 1954, 6, 425.Google Scholar
Fabing, H. D., Neurology, 1955a, 5, 603.Google Scholar
Idem, J.A.M.A., 1955b, 158, 1461.Google Scholar
Idem, J. Nerv. and Ment. Dis., 1956, 124, 1.CrossRefGoogle Scholar
Fedoroff, S., J. Lab. Clin. Invest., 1956, 48, 55.Google Scholar
Fischer, R., Science, 1953, 118, 409.Google Scholar
Freedman, A. M., and Ginsberg, V., “Exchange Transfusions in Schizophrenic Patients”, 1957. Read at Soc. Biol. Psych. Meeting, Atlantic City, N.J. Google Scholar
Funkenstein, D. H., Greenblatt, M., and Solomon, H. C., Amer. J. Psychiat., 1952, 108, 652.Google Scholar
Heath, R. G., Martens, S., Leach, B. E., Cohen, M., and Feigley, C. A., “Behavioural Changes in Non-Psychotic Volunteers following the Administration of Taraxein, the Substance obtained from the Serum of Schizophrenic Patients”, 1957a. Read at 113th Meeting A.P.A., Chicago, Ill. Google Scholar
Idem and Angel, C., Amer. J. Psychiat., 1957b, 114, 14.Google Scholar
Hoffer, A., Osmond, H., and Smythies, J., J. Ment. Sci., 1954, 100, 29.Google Scholar
Idem , Personal communication, 1957.Google Scholar
Lazell, E. W., and Prince, L. H., U.S. Vet. Bur. Med. Bull., 1929, 5, 40.Google Scholar
Leach, B. E., Cohen, M., Heath, R. G., and Martens, S., A.M.A. Arch. Neur. and Psych., 1956, 76, 635.Google Scholar
Lovett Doust, J. W., Husden, H., and Salna, M. E., Nature, 1956, 178, 492.Google Scholar
McGeer, P. L., McGeer, E. G., and Gibson, W. C., Science, 1956, 123, 1029.Google Scholar
Iidem and Boulding, J. E., ibid., 1956, 123, 1078.Google Scholar
Macht, D. I., Cincinnati J. Med., 1948, 20, 616.Google Scholar
Idem, South M.J., 1950, 43, 1049.Google Scholar
Osmond, H., Ann. N.Y. Acad. Sci., 1957, 66, 418.Google Scholar
Perri, G., “Irradiation of Tryptophan”, 1957. Read at Conf. on Biochemistry and Mental Illness, Univ. of Brit. Col., Vancouver, B.C., 20 June, 1957.Google Scholar
Pfeffer, A. Z., and Pescor, M. J., Arch. Neurol. and Psychiat., 1944, 52, 131.Google Scholar
Pincus, G., and Hoagland, H., Amer. J. Psychiat., 1950a, 106, 641.Google Scholar
Idem, ibid., 1950b, 106, 651.Google Scholar
Reiter, P. J., Zischr. f. d. ges. Neurol. u. Psychiat., 1938, 160, 598.Google Scholar
RIEGELHAUFT, L. M., J. Nerv. and Ment. Dis., 1956, 123, 383.Google Scholar
Idem , “Indolic Excretion of Schizophrenics”, 1957. Read at Conf. on Biochemistry and Mental Illness, Univ. Brit. Col. Vancouver, B.C., 20 June, 1957.Google Scholar
Rinkel, M., Hyde, R. W., and Solomon, H. C., Dis. Nerv. Syst. 1954, 15, 259.Google Scholar
Ross, E. L., Arch. Int. Med., 1913a, 12, 112.Google Scholar
Idem, ibid., 1913b, 12, 231.Google Scholar
Sherwood, W. K., Trans. Soc. Biol. Psychiat., 1956, 10, 53. Cincinnati: Merrell.Google Scholar
Idem , “Urinary Excretion of some Tryptophan Metabolites in Health and certain Diseases”, 1957. Unpublished MS. Google Scholar
Skoog, F., et al., “Symposium on Plant Growth Substances”, 1950. Univ. of Wisconsin Press.Google Scholar
Stoll, W. A., Schweiz. Arch. Neurol. u. Psychiat., 1947, 600, 279.Google Scholar
Sulkowitch, H., and Altschule, M. D., The Excretion of Urinary “Epinephrines”, in Psychiatric Disorders. In press.Google Scholar
Wada, J., “Behavioural and EEG changes induced by the Injection of an Extract of Schizophrenic Urine”, 1957. Read at Meeting of Soc. Biol. Psych., Atlantic City, N.J., June, 1957.Google Scholar
Winter, C. A., and Flataker, L., J. Pharmacol. Exper. Therap., 1951, 101, 156.Google Scholar
Idem, Proc. Soc. Exp. Biol. Med., 1956, 92, 285.Google Scholar
Idem , “The Effect of Blood Plasma from Psychotic Patients upon the Performance of Trained Rats”, 1957. Read at Soc. Biol. Psychiat. Meeting, Atlantic City, N.J. Google Scholar
Young, H. K. Jr., et al., Univ. of Texas Publ., 1951, 5109, 189.Google Scholar
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