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Psychological Effects of Centrally Acting Drugs in Man

Effects of Chlorpromazine and Secobarbital on Visual and Motor Behaviour

Published online by Cambridge University Press:  08 February 2018

Conan Kornetsky  and
Ogretta Humphries
Conan Kornetsky
Affiliation:
Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland
Ogretta Humphries
Affiliation:
Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland
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Extract

In a previous study (Kornetsky, Humphries and Evarts, 1957) it was found that the impairment of a variety of psychological processes caused by 200 mg. of chlorpromazine was not significantly less than the impairment produced by 200 mg. of secobarbital. It was also shown that the effects of drugs on psychological performance in man are related not only to the specific pharmacological activity of the drug, but also to the specific reactivity of the subject. It appeared that there was something unique to the individual which accounted for a significant portion of the effect of a drug. The present study was designed to extend these observations by reducing the number of drugs tested (in the previous study four drugs were used) and increasing the number of times a subject received each drug. It was hoped that this would give a better estimate of the effect of a specific dose of a specific drug and thus decrease the error of measurement and increase the reliability of the correlation between drugs.

Type
Original Articles
Information
Journal of Mental Science , Volume 104 , Issue 437 , October 1958 , pp. 1093 - 1099
Copyright
Copyright © Royal College of Psychiatrists, 1958 

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