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A Study of the Use of Azacyclonal Hydrochloride (“Frenquel”) in Chronic Schizophrenia

Published online by Cambridge University Press:  08 February 2018

C. F. Lascelles
Affiliation:
Cherry Knowle Hospital, Ryhope, near Sunderland
L. J. Levene
Affiliation:
Cherry Knowle Hospital, Ryhope, near Sunderland

Extract

In February, 1955, Howard D. Fabing described in Science (Fabing, 1955a) a clinical study using the drug azacyclonal hydrochloride (Frenquel), alpha-(4-piperidyl) benzhydrol hydrochloride. This drug is the gamma-isomer of Meratran which, although chemically similar, alpha-(2-piperidyl) benzhydrol hydrochlroide, has a rather different action. Brown and Werner (unpublished but referred to by Fabing, 1955a) reported that Frenquel prevents or diminishes central stimulation induced in the mouse by various agents, whereas Meratran has a stimulant action.

Type
Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

Clark, L. D., J. Nerv. Ment. Dis., 1956, 123, 557.Google Scholar
Fabing, H. D., Science, 1955a, 121, 208.Google Scholar
Idem, Neurology, 1955b, 5, 319.Google Scholar
Idem and Hawkins, J. R., Dis. Nerv. Syst., 1955, 16, 329.Google Scholar
Forster, W., and Henderson, A. L., Canad. med. Ass. J., 1957, 76, 97.Google Scholar
Gray, S., and Forrest, A. D., Brit. med. J., 1958, 1, 374.Google Scholar
Rinaldi, F., Rudy, L. H., and Himwich, H. E., Amer. J. Psychiat., 1955, 112, 343.CrossRefGoogle Scholar
Sargent, W., Brit. med. J., 1956, 1, 939.Google Scholar
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