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Schizophrenia: A New Approach

(Continued)

Published online by Cambridge University Press:  08 February 2018

H. Osmond  and
A. Hoffer
H. Osmond
Affiliation:
Saskatchewan Hospital, Weyburn, Saskatchewan
A. Hoffer
Affiliation:
Department of Public Health, University Hospital, Saskatoon, Saskatchewan
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Extract

In the April, 1952 issue of this journal, Osmond and Smythies (47) suggested that schizophrenia might be caused by a defect in adrenaline metabolism. They called this hypothetical adrenaline derivative “M-substance” because they endowed it with mescaline-like psychotomimetic qualities but with an effective potency nearer that of adrenaline or even the hugely powerful LSD-25. They showed that mescaline and adrenaline were sufficiently alike chemically for such an intermediate to be at least imaginable. In addition, they emphasized that the mescaline experience and the more acute and dramatic forms of schizophrenia have many similarities. They hoped that researchers would hunt diligently for our M-substance.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 440 , July 1959 , pp. 653 - 673
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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