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Phenothiazine Toxicity, Extrapyramidal Seizures, and Oculogyric Crises

Published online by Cambridge University Press:  08 February 2018

George Paulson
George Paulson*
Affiliation:
Clinical Neuropharmacology Research Center, National Institute of Mental Health, Washington, D.C.
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Extract

Prochlorperazine (Compazine, Stemetil) and chlorpromazine (Thorazine, Largactil) frequently produce tremor and rigidity. Less well known are the severe tonic spasms of the muscles of the head and neck which can result from these phenothiazine derivatives. This paper directs attention to these spasms and their similarity with “extrapyramidal seizures” and oculogyric crises.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 440 , July 1959 , pp. 798 - 802
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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