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Trifluoperazine (Stelazine) in Psychoneuroses

A Clinical Assessment

Published online by Cambridge University Press:  08 February 2018

A. R. May ,
J. Stuart Whiteley  and
B. G. Gradwell
A. R. May
Affiliation:
Department of Psychiatry, Westminster Hospital
J. Stuart Whiteley
Affiliation:
Department of Psychiatry, Westminster Hospital
B. G. Gradwell
Affiliation:
Department of Psychiatry, Westminster Hospital
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Extract

Trifluoperazine (Stelazine) is a phenothiazine derivative and is 2-trifluoromethyl-10-(3′ 1″-methyl piperazinyl-4″-propyl) phenothiazine dihydrochloride. It is related to prochlorperazine, and in fact differs only in having a trifluoromethyl group in place of the latter's chlorine atom in position 2 of the nucleus. However, in laboratory studies, tests based on the inhibition of conditioned responses have indicated that this compound was 5 times as effective as prochlorperazine and 10 times as potent as chlorpromazine on a weight for weight basis.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 441 , October 1959 , pp. 1059 - 1063
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

Garmany, G., May, A. R., and Folkson, A., Brit. med. J., 1954, ii, 439–441.CrossRefGoogle Scholar
Madgwick, J. R. A., McNeill, D. L. M., Driver, M., and Preston, G. C., J. Ment. Sci., 1958, 104, 1195–99.Google Scholar
Rudy, L. H., Rinaldi, F., Costa, E., Himwich, H. E., Tuteur, W., and Glotzer, J., Amer. J. Psychiat., 1958, 115, 364–65.Google Scholar
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