Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-18T23:44:42.422Z Has data issue: false hasContentIssue false

Susceptibility to Methylpentynol: Personality and Other Variables

Published online by Cambridge University Press:  08 February 2018

Allen A. Bartholomew
Affiliation:
Bethlem Royal and Maudsley Hospitals
Edward Marley
Affiliation:
Bethlem Royal and Maudsley Hospitals

Extract

Susceptibility to drugs is a biological variable, and Clark (1933a) remarks that for organisms sufficiently large to permit measurement of individual dosage, the curves relating dose and incidence of effect are sigmoid and can be assumed to express the individual variation of the population. Some of the variables determining drug response include age, sex and body weight (Goodman and Gilman, 1955). Although a relation between personality and drug response has always been alleged, Kennedy (1957) alluded to the lack of work in this field.

Type
Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1959 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bartholomew, A. A., Unpublished data, 1955.Google Scholar
Idem and Marley, E., J. Ment. Sci., 1959, 105, 238.Google Scholar
Idem , Bourne, G. L., and Marley, E., Clin. Sci., 1958, 17, 629.Google Scholar
Idem , Franks, C. M., and Marley, E., J. Ment. Sci., 1958, 104, 1167.Google Scholar
Idem , Chappell, P., Marley, E., and Chambers, J. S. W., Lancet, 1958, i, 346.Google Scholar
Beecher, H. K., J. Amer. med. Ass., 1955, 159, 1602.CrossRefGoogle Scholar
Clark, A. J., The Mode of Action of Drugs on Cells, 1933a. London: Arnold. p. 129.Google Scholar
Idem , ibid., 1933b. p. 106.Google Scholar
Davies, O. L., The Design and Analysis of Industrial Experiments, 1954. London: Oliver and Boyd. p. 45.Google Scholar
Dickel, H. A., and Dixon, H., J. Amer. med. Ass., 1957, 163, 422.CrossRefGoogle Scholar
Dundee, H. J., J. Irish med. Ass., 1952, 31, 351.Google Scholar
Eggleton, M. G., Brit. J. Psychol., 1941, 32, 52.Google Scholar
Eysenck, H. J., Structure of Human Personality. London: Methuen.Google Scholar
Idem , J. Ment. Sci., 1955, 101, 422.Google Scholar
Idem , Eugenics Review, 1956, 48, 23.Google Scholar
Eysenck, H. J. J. Ment. Sci., 1957a, 103, 119.Google Scholar
Idem , Rivista di Psicologica, 1957b, 4, 113.Google Scholar
Idem , The Dynamics of Anxiety and Hysteria, 1957c. London: Routledge and Kegan Paul. p. 248.Google Scholar
Franks, C. M., Brit. J. Psychol., 1957, 48, 119.Google Scholar
Idem and Laverty, S. G., J. Ment. Sci., 1955, 101, 654.Google Scholar
Gaddum, J. H., Lectures on the Scientific Basis of Medicine, 1956. London: Athlone Press. Vol. 4, p. 238.Google Scholar
Goodman, L. S., and Gilman, A., The Pharmacological Basis of Therapeutics, 1955. New York: Macmillan. 2nd ed. p. 10.Google Scholar
Guilford, J. P., and Guilford, R. B., J. Abnorm. soc. Psychol., 1934, 28, 377.CrossRefGoogle Scholar
Idem , J. Psychol., 1936, 2, 109.Google Scholar
Idem , J. Abnorm. soc. Psychol., 1939a, 34, 21.CrossRefGoogle Scholar
Idem , ibid., 1939b, 34, 239.Google Scholar
Kennedy, A., Brit. med. J., 1957, ii, 220.Google Scholar
McDouoall, W., J. Abnorm. soc. Psychol., 1929, 24, 293.Google Scholar
Marley, E., Lancet, 1955, ii, 535.CrossRefGoogle Scholar
Idem , Brit. J. Pharmacol., 1959, 14, 284.Google Scholar
Idem and Bartholomew, A. A., J. Neurol. Neurosurg. Psychiat., 1958, 21, 129.Google Scholar
Idem and Chambers, J. S. W., Brit. med. J., 1956, ii, 1467.Google Scholar
Idem and Vane, J. R., Brit. J. Pharmacol., 1958, 13, 364.Google Scholar
May, P. R. A., and Ebaugh, F. G., Amer. J. Psychiat., 1953, 109, 881.Google Scholar
Mellanby, E., “Alcohol: its absorption into and disappearance from the blood under different conditions”, 1919. M.R.C. Special Report Series, No. 31, p. 7.Google Scholar
Newman, H. W., Amer. J. Psychiat., 1935, 91, 1345.Google Scholar
Pampiolione, G., Proc. Roy. Soc. Med., 1958, 51, 79.Google Scholar
Pavlov, I. P., Conditioned Reflexes, 1927. Anrep, G. V. (trans.). London: Oxford University Press.Google Scholar
Perlman, P. L., Sutter, D., and Johnson, C., J. Amer. pharm. Ass. sci. ed., 1953, 42, 750.Google Scholar
Schaffarzick, R. W., and Brown, B. J., Science, 1952, 116, 663.Google Scholar
Shagass, C., EEG Clin. Neurophysiol., 1954, 6, 221.Google Scholar
Idem and Naiman, J., J. Psychosom. Res., 1956, 1, 49.Google Scholar
Thorpe, J. G., and Barker, J. C., Arch. Neurol. Psychiat., Chicago, 1957, 78, 194.CrossRefGoogle Scholar
Trouton, D. S., J. Ment. Sci., 1957, 103, 344.Google Scholar
Tucci, J. H., Brazier, M. A. B., Miles, H. H. W., and Finesinger, J. E., Anesthesiology, 1949, 25.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.