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The Use of Data from Low Frequency Analysis to Illustrate Serial EEG Changes in Depressed Patients During Treatment with Iproniazid

Published online by Cambridge University Press:  08 February 2018

E. Lettich  and
J. H. Margerison
E. Lettich
Affiliation:
Runwell Hospital, Wickford, Essex
J. H. Margerison
Affiliation:
Department of Clinical Neurophysiology, Maudsley Hospital, Denmark Hill, London; Runwell Hospital, Wickford, Essex, 1956–60
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Extract

Iproniazid, introduced as an anti-tubercular drug, has been widely used in the treatment of depression. It is a monoamine oxidase inhibitor and some of its effect on the central nervous system may therefore depend upon its preventing the breakdown of serotonin. It is hepatotoxic. Dally (2) and many others have commented upon a time lag of at least a week after the start of treatment before observable clinical improvement in depressed patients.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 444 , July 1960 , pp. 1111 - 1114
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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References

1 Agin, H. V., “The Use of J.B.-516 in Psychiatry”, Ann. Acad. Sci., 1959, 80, 705–711.CrossRefGoogle Scholar
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6 Parsons-Smith, B. G., Summerskill, W. H. J., Dawson, A. M., and Sherlock, S., “The Encephalograph in Liver Disease”, Lancet, 1957, ii, 867–871.Google Scholar
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