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Purines in the Urine of Normal and Schizophrenic Subjects

Published online by Cambridge University Press:  08 February 2018

Brenda M. Bollard ,
R. H. Culpan ,
N. Marks ,
H. McIlwain  and
Michael Shepherd
Brenda M. Bollard
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
R. H. Culpan
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
N. Marks
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
H. McIlwain
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
Michael Shepherd
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry (British Postgraduate Medical Federation, University of London) Maudsley Hospital, London, S.E.5
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Extract

Although there have been many attempts to discover in the body fluids, chemical peculiarities characteristic of schizophrenic illness, the outcome of most of these investigations has been inconclusive (see for example Altschule, 1953; Kety, 1959). Little attention has been paid, however, to purine metabolism until the recent studies of Kishimoto (1958) who reported peculiarities in the absorption spectra of body fluids in schizophrenia which he attributed to abnormalities in the conversion of adenine through hypoxanthine and xanthine to uric acid. These findings appeared to be supported by evidence which included the determination of urinary xanthine by a xanthine oxidase method based on that of Williams (1950).

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 445 , October 1960 , pp. 1250 - 1272
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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References

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