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Sedation Threshold, Personality, and the Theory of Neurosis

Published online by Cambridge University Press:  08 February 2018

G. S. Claridge  and
R. N. Herrington
G. S. Claridge
Affiliation:
Institute of Psychiatry (Maudsley Hospital), University of London
R. N. Herrington
Affiliation:
Royal Victoria Hospital, Netley
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Extract

For many years it has been observed that individuals differ in their tolerance of depressant drugs. In everyday life differential susceptibility to the effects of alcohol is that most commonly observed and this fact led to McDougall's early theorizing (1929) about drug tolerance and personality. Also at this time Pavlov, in dogs, recorded differences in drug sensitivity in his various temperamental types. However, the first attempt to measure individual differences in drug tolerance was made by Shagass (1954), who proposed the concept of “sedation threshold”. This was defined in terms of the amount of sodium amytal required to bring about certain behavioural and other changes in the individual, the threshold itself lying somewhere between the state of complete wakefulness and that of complete sedation. Two methods of determining the threshold were employed by Shagass. First, the point of onset of slurred speech gave an approximate estimate of its position. Secondly, a more accurate determination was made by means of EEG changes, specifically the point at which inflexion occurs in the amplitude curve of induced fast frontal activity.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 445 , October 1960 , pp. 1568 - 1583
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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