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Therapeutic Value of Thioproperazine and the Importance of the Associated Neurological Disturbances

Published online by Cambridge University Press:  08 February 2018

J. Denham  and
D. J. E. L. Carrick
J. Denham
Affiliation:
Long Grove Hospital, Epsom
D. J. E. L. Carrick
Affiliation:
Long Grove Hospital, Epsom
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Extract

Clinical trials of thioproperazine (7843 R.P.; “Majeptil”) 2-dimethyl-sulphamoyl-10-(3-4′-methy1-1′-piperazinylpropyl) phenothiazine methanesulphonate, carried out in France by Delay, Deniker et al. (1959b); Perrin, Lambert et al. (1958); Coirault et al. (1959); and in America by Denber et al. (1959, 1960), have shown that it is a highly effective agent in the treatment of schizophrenia and acute mania. To examine the claims made for the drug's value in deteriorated or vegetative schizophrenics, and in other cases that have resisted chemotherapy, a trial was undertaken in this country.

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 447 , March 1961 , pp. 326 - 345
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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