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A Trial of Hypoglycaemic Agents for Weight Increase in Psychiatric Patients

Published online by Cambridge University Press:  08 February 2018

Susanne Shafar
Susanne Shafar*
Affiliation:
Crumpsall Hospital, Manchester
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Extract

Former attempts to restore weight loss in psychiatric patients have included hyperalimentation (Weir Mitchell, 8) and sub-coma insulin therapy (Debenham et al., 2; Sargant and Craske, 5; Sullivan, 7). The aim of the present trial was to compare weight gains in a group of patients given repeated small doses of insulin with two other groups to whom oral hypoglycaemic agents were administered, and with a control group. The drugs used were tolbutamide and chlorpropamide, both of which are sulphonylureas used in the management of diabetes mellitus, and known to induce hypoglycaemia in non-diabetic subjects (Hoenig and Gittleson, 4; Cardonnet et al., 1; Garcia Reyes et al., 3). Pharmacologically there are no qualitative differences in their mode of action. Stowers et al., (6) found the half-life of tolbutamide to be 3·5 hours and that of chlorpropamide 34·5 hours. The prolonged action of chlorpropamide permits once daily dosage, but tolbutamide, being a shorter acting drug, was given in divided doses to maintain depression of blood sugar over the 24 hours.

Type
Tberapy
Information
Journal of Mental Science , Volume 108 , Issue 454 , May 1962 , pp. 371 - 372
Copyright
Copyright © Royal College of Psychiatrists, 1962 

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References

1. Cardonnet, L. J., Staffieri, J. J., Eberhardt, D. R., Tommasino, P. O., Beru, R. R., and Muratorio, J., Ann, N. Y. Acad. Sci., 1959, 74 (3), 771.Google Scholar
2. Debenham, G. R., Hill, D., Sargant, W., and Slater, E., Lancet, 1941, ii, 212.Google Scholar
3. Garcia, , Reyes, J. A., Pena, J. C., Barroso, E., Anton, F. B. S., and Gonzalez, C., Ann. N. Y. Acad. Sci., 1959, 74 (3), 1012.Google Scholar
4. Hoenig, J., and Gittleson, N., “Weight Gaining. A therapeutic trial with Tolbutamide”. Brit. Med. J., 1961, 2, 1403.Google Scholar
5. Sargant, W., and Craske, N., Lancet, 1941, 2, 212.Google Scholar
6. Stowers, J. M., Constable, L. W., and Hunter, R. B., Ann. N. Y. Acad. Sci., 1959, 74 (3), 689.CrossRefGoogle Scholar
7. Sullivan, D. J., Arch. Neurol. and Psychiat., 1948, 59, 184.CrossRefGoogle Scholar
8. Weir Mitchell, S., Fat and Blood 4th ed., 1885, Lippincott.Google Scholar
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