Hostname: page-component-848d4c4894-m9kch Total loading time: 0 Render date: 2024-05-10T17:27:13.432Z Has data issue: false hasContentIssue false
  • English
  • Français

A clinical comparison of phenelzine and electro-convulsive therapy in the treatment of depressive illness

Published online by Cambridge University Press:  08 February 2018

W. J. Stanley  and
H. Fleming
W. J. Stanley
Affiliation:
Winwick Hospital' Warrington, Lancs
H. Fleming
Affiliation:
Winwick Hospital
Get access Rights & Permissions [Opens in a new window]

Extract

The mono-amine oxidase inhibitors, of which phenelzine (“Nardil”) is one example, were introduced for the treatment of depressive illness as a result of the observation that iproniazid, which is a mono-amine oxidase inhibitor, produced euphoria and increased mental alertness in some tuberculous patients to whom it was given. Trials of iproniazid in mental illness were carried out (Loomer et al., 1957; Cesarman, 1959), but it was found to be very liable to give rise to side-effects, being particularly toxic to the liver. Other less toxic mono-amine oxidase inhibitors such as phenelzine, which is chemically related to iproniazid, were later developed.

Type
Therapeutic Trials
Information
Journal of Mental Science , Volume 108 , Issue 456 , September 1962 , pp. 708 - 710
Copyright
Copyright © Royal College of Psychiatrists, 1962 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Annotation on Monoamine Oxidase Inhibitors (1959). B.M.J., ii, 1238.Google Scholar
Cesarman, T. (1959). Ann. N. Y. Acad. Sci., 80, 553.Google Scholar
Foulds, G. A., and Caine, T. M. (1959). J. Ment. Sci., 105, 182.Google Scholar
Loomer, H. P., Saunders, J. C., and Kline, N. S. (1957). Psych. Res. Rep. Amer. Psychiat. Ass. 8, 129.Google Scholar
McCall, R. J. (1958). J. Clin. Psychol., 14, 1.3.0.CO;2-Q>CrossRefGoogle Scholar
Siegel, S. (1956). Non-parametric Statistics for the Behavioural Sciences. London: McGraw-Hill.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.