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Amitriptyline: A controlled trial in chronic depressive states

Published online by Cambridge University Press:  08 February 2018

Andrew Skarbek  and
Daphne Smedberg
Andrew Skarbek
Affiliation:
University College, London W.C.1
Daphne Smedberg
Affiliation:
Cane Hill Hospital, Coulsdon, Surrey
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Extract

Amitriptyline hydrochloride is 5–(3 dimethylaminopropylidine)–dibenzo (a,d) (1,4) cycloheptadiene hydrochloride. Structurally it is not related to the hydrazines and is not a monoamine oxidase inhibitor. It bears some resemblance to the phenothiazines and its chemical structure is related to imipramine, in which the central seven numbered ring is azepine, nitrogen replacing the partially unsaturated carbon of the amitriptyline cycloheptadiene ring (Dorfman, 1960; Vernier, 1961).

Type
Clinical Trials
Information
Journal of Mental Science , Volume 108 , Issue 457 , November 1962 , pp. 859 - 861
Copyright
Copyright © Royal College of Psychiatrists, 1962 

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References

Bradford Hill, A. (1955). Principles of Medical Statistics, 6th Ed., 288.Google Scholar
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Vernier, V. G. (1961). Dis. Nerv. Syst. (Supp.), 22, 7.Google Scholar
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