(1) A controlled, blind trial of ascorbic acid saturation, involving 40 male, chronic psychiatric patients, is described.
(2) Standardized (objective and subjective) psychological techniques were used to assess changes dependent upon ascorbic acid intake.
(3) A clinical state of subscurvy was found in these patients.
(4) Psychiatric patients are shown to have an unusually high demand for ascorbic acid.
(5) Statistically significant improvement in the depressive, manic and paranoid symptom-complexes, together with an improvement in overall personality functioning, was obtained following saturation with ascorbic acid.
(6) It is suggested that chronic psychiatric patients would benefit from the administration of ascorbic acid.