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A Clinical Trial of Amitriptyline in Depressive Patients

Published online by Cambridge University Press:  29 January 2018

M. W. Browne ,
L. C. Kreeger  and
N. G. Kazamias
M. W. Browne
Affiliation:
Fairdene and Netherne Hospitals, Coulsdon, Surrey
L. C. Kreeger
Affiliation:
Shenley Hospital, Netherne Hospital and the Westminster Hospital
N. G. Kazamias
Affiliation:
Netherne Hospital
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Extract

Amitriptyline (Tryptizol) is an antidepressant drug which is related structurally to imipramine (Fig. 1). Its full name chemically is 5-(d-dimethylaminopropylidene)-dibenzo (a,d) (1,4) cycloheptadiene hydrochloride. Numerous uncontrolled trials to date (Ayd, Bennett) have reported success with this drug in the treatment of both endogenous and reactive depressions. Several reports (Ayd, Dorfman, Dunlop) have stressed the fact that agitation as a manifestation of depressive illness is frequently relieved. The purpose of this study was to assess the effect of the drug on depression in a controlled trial.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 109 , Issue 462 , September 1963 , pp. 692 - 694
Copyright
Copyright © Royal College of Psychiatrists, 1963 

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References

Ayd, F. J. Jr. Psychosomatics, Vol. 1, No. 6, November–December, 1960.Google Scholar
Bennett, D. Lancet (Letter). 10 June, 1961.Google Scholar
Dorfman, W. Psychosomatics, Vol. 1, No. 3, May–June, 1960.Google Scholar
Dunlop, E. Diseases of Nervous System. Supp. Vol. XXII. No. 5, May, 1961.Google Scholar
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