Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-23T18:13:27.468Z Has data issue: false hasContentIssue false
  • English
  • Français

The Influence of Case Selection and Dosage in an Antidepressant Drug Trial

Published online by Cambridge University Press:  29 January 2018

Myron G. Sandifer Jr. ,
Ian C. Wilson  and
John M. Gambill
Myron G. Sandifer Jr.
Affiliation:
Department of Mental Health, Raleigh, North Carolina
Ian C. Wilson
Affiliation:
Broughton Hospital, now Department of Mental Health, Raleigh, North Carolina
John M. Gambill
Affiliation:
Broughton Hospital, Morganton, North Carolina
Get access Rights & Permissions [Opens in a new window]

Extract

The sheer volume of new drugs introduced into psychiatry within the past decade has created an urgency to get to the point as quickly as possible: Is Drug B better than A, and, if so, what about B and C? With some abatement of the tide of new compounds it becomes possible to look, not just for a quick answer, but at some of the conditions of the trial which determine the outcome.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 471 , February 1965 , pp. 142 - 148
Copyright
Copyright © Royal College of Psychiatrists, 1965 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

References

Angst, J. (1963). “Comparison of the antidepressant properties of amitriptyline and imipramine.” Psychopharmacologia, 4, 389–401.CrossRefGoogle Scholar
Ayd, F. (1960). “Amitriptyline (Elavil) therapy for depressive reactions.” Psychosomatics, 1, 320–325.CrossRefGoogle Scholar
Ayd, F. J. (1961). “A critique of antidepressants.” Dis. Nerv. Syst., 22 (suppl.), 32–36.Google Scholar
Ball, J. R. B., and Kiloh, L. G. (1959). “A controlled trial of imipramine in depressive states.” Brit. med. J., 5159, 1052–1055.CrossRefGoogle Scholar
Bennett, D. (1961). “Treatment of depressive states with imipramine.” Dis. Nerv. Syst., 22, 55–56.Google Scholar
Burt, C. G., Gordon, W. F., Holt, N. F., and Hordern, A. (1962). “Amitriptyline in depressive states.” J. Ment. Sci., 108, 711–730.CrossRefGoogle Scholar
Dorfman, W. (1960). “Clinical experiences with amitriptyline.” Psychosomatics, 1, 153–155.CrossRefGoogle Scholar
Edelstein, E. L. (1962). “Amitriptyline therapy in depressive states combined with anxiety.” Dis. Nerv. Syst., 23, 644–647.Google Scholar
Freyhan, F. (1960). “The modern treatment of depressive disorders.” Amer. J. Psychiat., 116, 1057–1064.CrossRefGoogle Scholar
Friedman, C., Mowbray, M. S., and Hamilton, V. J. (1961). “Imipramine (Tofranil) in depressive states.” J. Ment. Sci., 107, 948–953.CrossRefGoogle Scholar
Garry, J. W., and Leonard, T. J. (1963). “Trial of amitriptyline in chronic depression.” Brit. J. Psychiat., 109, 54–55.CrossRefGoogle Scholar
Gottlieb, G., and Paulson, G. (1961). “A longitudinal study of electroencephalographic arousal response in depressed patients.” J. Nerv. and Ment. Dis., 133, 524–528.Google Scholar
Hamilton, M. (1960). “A rating scale for depression.” J. Neurol. Neurosurg. Psychiat., 23, 56–62.CrossRefGoogle Scholar
Hordern, A., Holt, N. F., Burt, C. G., and Gordon, W. F. (1963). “Amitriptyline in depressive states.” Brit. J. Psychiat., 109, 815–825.CrossRefGoogle Scholar
Hutchinson, J. T., and Smedbero, D. (1963). “A comparative study of E.C.T. and six drugs.” Ibid., 109, 536–538.Google Scholar
Martin, M. E. (1963). “A comparative study of imipramine and phenelzine.” Ibid., 109, 279–285.Google Scholar
Oltman, J. E., and Freedman, S. (1961). “Elavil in the treatment of affective disorders.” Amer. J. Psychiat., 118, 546–547.CrossRefGoogle Scholar
Physician's Desk Reference (1963). Medical Economics, Oradell, New Jersey, p. 757.Google Scholar
Pressman, M. D., and Weiss, L. B. (1961). “Experiences with Elavil: treatment of 51 cases of depression.” Amer. J. Psychiat., 118, 74–75.CrossRefGoogle Scholar
Sandifer, M. G., Dunham, R. M., and Howard, K. (1961). “The reporting and design of research in psychiatric drug treatment: a comparison of two years.” Psychopharmacol. Service Center Bull., 6–10. July.Google Scholar
Sandifer, M. G., Pettus, C. W., and Quade, D. (1964). “A study of psychiatric diagnosis.” J. Nerv. Ment. Dis. In press.CrossRefGoogle Scholar
Skarbek, A. (1963). “Trial of amitriptyline in chronic depression.” Dis. Nerv. Syst., 24, 115–119.Google Scholar
Webs, L. B., and Pressman, M. D. (1961). “A comparison of imipramine (Tofranil) and amitriptyline (Elavil) in the treatment of depression.” Psychosomatics, 2, 293–296.Google Scholar
Wilson, I. C., Gambill, J. M., and Sandifer, M. G. (1963). “Loeffler's syndrome occurring during imipramine therapy.” Amer. J. Psychiat., 119, 892–893.CrossRefGoogle Scholar
Wilson, I. C., Vernon, J. T., Gum, T., and Sandifer, M. G. (1963). “A controlled study of the treatments of depression.” J. Neuropsychiat., 4, 331–337.Google Scholar
Wilson, I. C., Gambill, J. M., and Sandifer, M. G. (1964). “A double blind trial comparing imipramine (Tofranil) with desmethylimipramine (Pertofrane).” Psychosomatics. In press.CrossRefGoogle Scholar
Wittenborn, J. R., Plante, M., Burgess, F., and Maurer, H. (1962). “A comparison of imipramine, electro-convulsive therapy and placebo in the treatment of depression.” J. Nerv. Ment. Dis., 135, 131–137.CrossRefGoogle Scholar

Group A References

Ball, J. R. B., 1959; Freyhan, F., 1960; Martin, M. E., 1963; Wilson, I. C., et al., 1964; Wilson, I. C., Vernon, J. T. et al., 1963; Wittenborn, J. R. et al., 1962.Google Scholar

Group B References

Ayd, F., 1960; Burt, G. G. et al., 1962; Dorfman, W., 1960; Edelstein, E. L., 1962; Garry, J. W. et al., 1963; Hordern, A. et al., 1963; Skarbek, A., 1963.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.