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A Single-Patient, Self-Controlled and Self-Recorded Trial of Wy 3498

Published online by Cambridge University Press:  29 January 2018

Frank M. McPherson  and
John Le. Gassicke
Frank M. McPherson
Affiliation:
Department of Psychological Medicine, University of Edinburgh, Professorial Unit, Jordanburn Nerve Hospital, Edinburgh, 10
John Le. Gassicke
Affiliation:
Department of Psychological Medicine, University of Edinburgh, Professorial Unit, Jordanburn Nerve Hospital, Edinburgh, 10
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Extract

This paper describes the preliminary clinical testing of a new sedative drug, and also explores the feasibility of using a single-patient, self-controlled and recorded design in psychiatric drug trials. Hogben and Sim (1953) demonstrated a form of drug trial which emphasized intra-subject fluctuations and their control. Recently, Shapiro (1963) has argued the usefulness of a similar approach in fundamental, clinical research. However, the single-patient drug trial appears not to have been widely used in psychiatry, although several writers, e.g. Shepherd (1963), have indicated its possible advantages.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 471 , February 1965 , pp. 149 - 154
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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