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The Management of Depression in Hospital

A Comparative Trial of Desipramine and Imipramine

Published online by Cambridge University Press:  29 January 2018

John Waldron  and
T. J. N. Bates
John Waldron
Affiliation:
Saxondale Hospital, Radcliffe-on-Trent, Nottinghamshire
T. J. N. Bates
Affiliation:
Mapperly Hospital, Nottingham
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Extract

Desipramine (Pertofran) is a metabolite of imipramine (Tofranil) originally isolated by Herrmann, Schindler and Pulver (1959) and found to be identical with the synthetic compound G.35025. Animal experiments (Gillette et al., 1961) suggest a more rapid action for desipramine, and the majority of clinical trials to date confirm this impression for humans (e.g. Kline et al., 1962; Krakowski, 1963). Some controlled trials, however, (Azima et al., 1962; Hollister et al., 1963) fail to establish that desipramine is either faster acting or more effective than imipramine.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 475 , June 1965 , pp. 511 - 516
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

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