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Preliminary Evaluation of a New Anti-Depressant, Trimipramine, by a Sequential Method

Published online by Cambridge University Press:  29 January 2018

B. H. Burns
B. H. Burns*
Affiliation:
Department of Psychiatry, University of Manchester, Gaskell House Annexe, Swinton Grove, Manchester 13
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Extract

A new drug, trimipramine (Surmontil, 7162 R.P.), has been found to have a specific antidepressant effect (Lambert et al., 1961), and has been used in France for two years; hitherto no controlled trial of trimipramine has been published. This paper reports a three weeks' comparative trial between this drug and imipramine (Tofranil), in the treatment of psychotic depression, using the statistical method of sequential analysis, the actual design used was that at the 5 per cent. chance level (Armitage, 1960).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 481 , December 1965 , pp. 1155 - 1157
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

Armitage, P. (1960). Sequential Medical Trials, p. 37. Oxford: Blackwell Scientific Publications.Google Scholar
Bourrat, C, Appeau, A., and Billeger, J. (1963). “Convulsive seizures occurring during treatment with trimipramine.” Lyon Médical, 33, 246.Google Scholar
Gandini, S., Gandini-Collodel, E., and Ferromilone, F. (1962). “Clinical observations on a new pharmaceutical product with an anti-depressant activity derived from iminodibenzyl (FI 6120).” Riv. di Neurobiol., 8, 241–242.Google Scholar
Lambert, P. A., Guyotat, J., and Charriot, G. (1961). “Trimipramine (7162 RP) a new anti-depressant with sedative and tranquillizing properties.” Ann. Méd.-Psychol., 2, 713–716.Google Scholar
Lambert, P. A., Guyotat, J., Chapot, G., and Charriot, G. (1963). “Regarding convulsive accidents induced by various derivatives of iminodibenzyl.” L'Encéphale, 52, 244–246.Google Scholar
Vauthier, G. (1963). “First results of the use of trimipramine, new thymoleptic sedative in psychiatric out-patients.” Med. and Hygiene, 604, 676.Google Scholar
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