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Changes in Urine Volume and Diurnal Rhythm caused by Reserpine Treatment of Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

Axel Randrup  and
Ib Munkvad
Axel Randrup
Affiliation:
St. Hans Hospital, Department E., Roskilde, Denmark
Ib Munkvad
Affiliation:
St. Hans Hospital, Department E., Roskilde, Denmark
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Extract

During a study of schizophrenic patients under prolonged treatment with reserpine alternating with placebo, night and day portions of urine were sampled for the determination of 4.-hydroxy-3-methoxymandelic acid (VMA). We found that reserpine treatment caused a moderate decrease in the excretion of this metabolite of adrenaline and noradrenaline, as reported in detail elsewhere (Munkvad and Randrup). We also observed certain characteristic changes in urine volume and diurnal rhythm, and these changes will be reported on in the present paper.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 112 , Issue 483 , February 1966 , pp. 173 - 176
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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