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Parental Age and Schizophrenia

Published online by Cambridge University Press:  29 January 2018

K. L. Granville-Grossman*
Affiliation:
Queen Elizabeth II Hospital, Welwyn Garden City, Herts

Extract

Reports that schizophrenics have older parents than non-schizophrenics (Barry, 1945; Goodman, 1957; Johanson, 1958; Gregory, 1959) are of considerable importance. If valid, they provide evidence for environmental causes of schizophrenia, and by analogy with other conditions where parental age effects have been noted may give some indication of the nature of these causes. There are, however, inconsistencies in these studies: thus Johanson and Gregory found a significant association between advanced paternal age and schizophrenia, but failed to confirm the maternal age effect noted by Barry and Goodman. These differences indicate the need for further investigation and this paper describes such a study.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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References

Barry, H. (1945). “Incidence of advanced maternal age in mothers of 1000 State hospital patients”. Arch. Neurol. Psychiat. (Chic.), 54, 186191.CrossRefGoogle Scholar
Blank, C. E. (1900). “Apert's syndrome (a type of acrocephalosyndactyly)—observations on a British series of 39 cases”. Ann. hum. Genet., 24, 151164.Google Scholar
Ferguson-Smith, M. A. Mack, W. S. Ellis, P. M. Dickson, M. Sanger, R. and Race, R. R. (1964). “Parental age and the source of the X chromosome in XXY Klinefelter's syndrome”. Lancet, i, 46.Google Scholar
Frøland, A. Johnsen, S. G. Andresen, P. Dein, E. Sanger, R. and Race, R. R. (1963). “Non-disjunction and XXY Men”. Lancet, ii, 11211122.Google Scholar
Goodman, N. (1957). “Relation between maternal age at parturition and incidence of mental disorder in the offspring”. Brit. J. prev. soc. Med., 11, 203213.Google Scholar
Gregory, I. (1959). “An analysis of family data on 1000 patients admitted to a Canadian mental hospital”. Acta genet. (Basel), 9, 5496.Google Scholar
Hill, A. Bradford (1955). Principles of Medical Statistics. London.Google Scholar
Huxley, J. Mayr., E. Osmond, H. and Hoffer, A. (1964). “Schizophrenia as a genetic morphism”. Nature, 204, 220221.Google Scholar
Johanson, E. (1958). “A study of schizophrenia in the male”. Acta psychiat. scand., 33, Supp. 125.Google Scholar
Johnston, A. W. Ferguson-Smith, M. A. Handmaker, S. D. Jones, H. W. and Jones, G. S. (1961). “The Triple X syndrome: clinical, pathological and chromosomal studies in three mentally retarded cases”. Brit. med. J., 2, 10461052.Google Scholar
Kidd, C. B. Knox, R. S. and Mantle, D. J. (1963). “A psychiatric investigation of Triple X Chromosome females”. Brit. J. Psychiat., 109, 9094.Google Scholar
Lewis, A. J. (1958). “Fertility and mental illness”. Eugen. Rev., 50, 91106.Google Scholar
Moran, P. A. P. (1965). “Schizophrenia and maternal age at parturition”. Ann. hum. Genet., 28, 269272.Google Scholar
Nielsen, J. P. (1964). “Prevalence of Klinefelter's syndrome in patients with mental disorders”. Lancet, i, 1109.Google Scholar
Ødegaard, O. (1932). Emigration and Insanity. Acta psychiat. neurol. (Copenhagen) Supp. 4.Google Scholar
Penrose, L. S. (1955). “Parental age and mutation”. Lancet, ii, 312313.CrossRefGoogle Scholar
Penrose, L. S. (1956). “Estimate of the incidence of cases of schizophrenia and manic-depressive reaction due to spontaneous mutation”, in Appendix E. Hazards to Man of Nuclear and Allied Radiation, London: H.M.S.O.Google Scholar
Penrose, L. S. (1957). “Parental age in achondroplasia and mongolism”. Amer. J, hum. Genet, 9, 167169.Google Scholar
Shields, J. and Slater, E. (1960). “Heredity and psychological abnormality”, in Handbook of Abnormal Psychology (ed. Eyscnck, H. J.). London.Google Scholar
Smith, D. W. Patau, K. and Therman, E. (1961). “Autosomal trisomy syndromes”, Lancet, ii, 211212.CrossRefGoogle Scholar
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