In previous papers (2, 3) we have set forth our neurophysiopathogenic theory of alcoholism, which is an amplification of Jellinek's hypothesis (1) that the gamma and delta types of alcoholism form an addictive disease. The physical dependence characterized by a state of distress and an overpowering desire to consume more ethanol, assumes three forms: (a) “inability to stop” the ingestion (Jellinek's “loss of control”) noted moments after ingesting a small quantity of ethanol following a period of abstinence, which characterizes the gamma or intermittent clinical form of alcoholism; (b) “inability to abstain” from ethanol hours after the last ingestion and after continuous drinking (each 4 to 8 hours during months or years), which characterizes the delta or inveterate clinical form of alcoholism, and (c) primary physical dependence without ethanol having necessarily been ingested previously, which characterizes remittent, or epsilon alcoholism or dipsomania.