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Variations in Body Water during Recovery from Depression

Published online by Cambridge University Press:  29 January 2018

R. P. Hullin ,
Angela D. Bailey ,
R. McDonald ,
G. A. Dransfield  and
H. B. Milne
R. P. Hullin
Affiliation:
University of Leeds
Angela D. Bailey
Affiliation:
University of Leeds
R. McDonald
Affiliation:
High Royds Hospital, Menston, Ilkley, Yorkshire
G. A. Dransfield
Affiliation:
High Royds Hospital, Menston, Ilkley, Yorkshire
H. B. Milne
Affiliation:
High Royds Hospital, Menston, Ilkley, Yorkshire
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Extract

Reports of significant changes in water and electrolytes during recovery from depression may provide insight into important physiological factors in depressive illnesses. Brown et al. (1963) demonstrated an increase in the extracellular fluid volume in 22 of 28 patients suffering from primary depressive disorders treated with E.C.T. or imipramine. The findings of these authors, which were discussed in relation to previous work on sodium metabolism and water balance in depressive disorders, were thought to support the idea of a shift of fluid from intracellular to extracellular spaces during the response to treatment. Coppen and Shaw (1963) found an increase in total body water, extracellular fluid and a decrease in the residual sodium space on recovery from depression.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 499 , June 1967 , pp. 573 - 583
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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