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Correlation of Clinical Features of Depressed Out-Patients with Response to Amitriptyline and Protriptyline

Published online by Cambridge University Press:  29 January 2018

N. McConaghy ,
A. D. Joffe ,
W. R. Kingston ,
H. G. Stevenson ,
I. Atkinson ,
E. Cole  and
L. A. Fennessy
N. McConaghy
Affiliation:
School of Psychiatry
A. D. Joffe
Affiliation:
Department of Statistics, University of New South Wales, Sydney
W. R. Kingston
Affiliation:
Alfred Hospital, Melbourne
H. G. Stevenson
Affiliation:
Alfred Hospital, Melbourne
I. Atkinson
Affiliation:
Alfred Hospital, Melbourne
E. Cole
Affiliation:
Alfred Hospital, Melbourne
L. A. Fennessy
Affiliation:
Department of Psychiatry, St. Vincent's, Melbourne
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Extract

Considerable inconsistency exists in the literature concerning the clinical features of depression associated with a good response to anti-depressant medication. Abraham et al. (1963) summarized the literature to that date; the general consensus of opinion was that imipramine had its best effect in depressions of the endogenous rather than those of the neurotic type, but their study on depressed out-patients did not support this conclusion. Browne et al. (1963), working with in-patients, reported that reactive depressives showed a better response to amitriptyline than did endogenous depressives. Burt et al. (1962), in their report of the response of 73 depressed female in-patients treated with imipramine or amitriptyline, demonstrated a much better response to both drugs by reactive as compared with endogenous depressives. Spear et al. (1964) found no significant difference in respect to “endogenicity”, in the response of depressed in- and out-patients to tranylcypromine and imipramine. Richmond and Roberts (1964) reported that out-patients suffering from endogenous depression responded much better to a variety of anti-depressant drugs than did those suffering from reactive depression.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 506 , January 1968 , pp. 103 - 106
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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References

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