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The use of Pericyazine and Chlorpromazine with Disturbed Mentally Subnormal Patients

Published online by Cambridge University Press:  29 January 2018

T. W. H. Weir
Affiliation:
Muckamore Abbey Hospital
G. A. Kernohan
Affiliation:
Muckamore Abbey Hospital; Downshire Hospital, Downpatrick
D. N. Mackay
Affiliation:
Muckamore Abbey Hospital, Co. Antrim, Northern Ireland

Extract

This report describes a clinical trial in which pericyazine and chlorpromazine were used with 45 disturbed patients resident in a hospital for the mentally subnormal. The patients, who comprised a clinically heterogeneous sample, were randomly allocated by the hospital pharmacist to two major groups; in one, half the patients were given pericyazine for a 12-week period and an inert preparation for a further 12-week period while the remaining patients had the inert preparation during the first period and pericyazine during the second. In the other group, which was given chlorpromazine, the same procedure was followed. Prior to the trial proper, there was a six-week period during which all drugs except anti-convulsants were tapered off. All preparations were in syrup form and were indistinguishable from each other by taste or smell. Only the pharmacist was aware of what syrup a given patient received.

Type
Abstract
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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References

Hunter, H., and Stephenson, A. M. (1963). “Chlorpromazine and trifluoperazine in the treatment of behaviour abnormalities in the severely subnormal child.” Brit. J. Psychiat., 109, 411417.CrossRefGoogle Scholar
Siegel, S. (1956). “Nonparametric Statistics.” London: McGraw Book Company, Inc.Google Scholar
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