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The False Drug Side-Effect: Which Patients Complain

Published online by Cambridge University Press:  29 January 2018

William S. Appleton
William S. Appleton*
Affiliation:
Massachusetts Mental Health Center, and Instructor in Psychiatry, Harvard Medical School; Address: Massachusetts Mental Health Center, 74 Fenwood Road, Boston, Massachusetts 02115
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Extract

At the Massachusetts Mental Health Center (M.M.H.C.), a well-staffed university psychiatric hospital, an outbreak of alleged chlorpromazine-induced skin rashes recently occurred involving five dramatic young female patients. Investigation of the complaints led us to doubt whether medication was the cause. Why then did these women blame chlorpromazine? Thus, the central concern of this investigation: which patients are likely to complain of drug-induced side-effects and under what conditions? A second issue arising from our study and described in the literature is the need for care when differentiating the true from the alleged medication side-effect.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 507 , February 1968 , pp. 197 - 201
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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References

1. Appleton, W. (1963). “Massive doses of chlorpromazine” Arch. gen. Psychiat., 9, 586–592.CrossRefGoogle Scholar
2. Appleton, W. (1965). “The snow phenomenon: tranquillizing the assaultive” Psychiat., 28, 88–93.CrossRefGoogle Scholar
3. Beecher, H. K. (1955). “Powerful placebo” J.A.M.A., 159, 1602–1606.Google Scholar
4. Busfield, B., Schneller, P., and Capra, D. (1962). “Depressive symptom or side-effect ? A comparative study of symptoms during pre-treatment and treatment periods of patients on three antidepressant medications” J. nerv. ment. Dis., 134, 339–345.CrossRefGoogle Scholar
5. Caudill, W. A. (1958). The Psychiatric Hospital as a Small Society. Cambridge, Massachusetts: Harvard University Press.Google Scholar
6. Chien, C. P., and Appleton, W. (1967). “Teaching of psychopharmacology: treatment orientation and learning of first year residents.” (To be published.) Google Scholar
7. Gartner, M. A. (1961). “Selected personality differences between placebo reactors and non-reactors” J. Amer. osteop. Assoc., 60, 377–378.Google Scholar
8. Glaser, E. M., and Whittow, G. C. (1953). “Evidence for a non-specific mechanism of habituation” J. Physiol., 122, 43–44.Google Scholar
9. Green, D. M. (1962). “Side Effects” Fed. Proc., 21, 179 (Abstract).Google Scholar
10. Greenblatt, M., Grosser, G., and Wechsler, H. (1964). “Differential response of hospitalized depressed patients to somatic therapy” Amer. J. Psychiat., 120, 935–943.CrossRefGoogle Scholar
11. Hankoff, L. D. (1962). “Treatment comparison and the placebo effect” Dis. nerv. Syst., 23, 39–40.Google Scholar
12. Honigfeld, G. (1963). “The ability of schizophrenics to understand normal, psychotic, and pseudopsychotic speech” Dis. nerv. Syst., 24, 692–694.Google Scholar
13. Honigfeld, G. (1964). “Non-specific factors in treatment. 1. Review of placebo reactions and placebo reactors” Ibid., 25, 145–156.Google Scholar
14. Honigfeld, G. (1964). “Non-specific factors in treatment. 2. Review of social-psychological factors” Ibid., 25, 225–239.Google Scholar
15. Kasich, A. M., Fein, H. D., and Miller, J. W. (1959). “Comparative effect of phenaglycodol, meprobamate, and a placebo on the irritable colon; a double-blind study” Amer. J. digest. Dis., 4, 229–234.Google Scholar
16. Klerman, G. L. (1965). “The teaching of psychopharmacology in the psychiatric residency” Comp. Psychiat., 6(4), 255–264.CrossRefGoogle Scholar
17. Meanock, R. I., and Lewis-Faning, E. (1961). “A controlled trial of phenylbutazone, oxyphenbutazone, and a placebo in the treatment of rheumatoid arthritis” Ann. rheum. Dis., 20, 161–172 CrossRefGoogle Scholar
18. Medical Research Council (1950). “Clinical trials of antihistaminic drugs in the prevention and treatment of the common cold” Brit. med. J., 2, 425–429.Google Scholar
19. Pogge, R. (1963). “The toxic placebo” Medical Times, 91, 773–778.Google Scholar
20. Sheard, M. H. (1963). “The influence of doctor's attitude on the patient's response to antidepressant medication” J. nerv. ment. Dis., 136, 555–560.Google Scholar
21. Wolf, S. (1953). “Toxic effects of placebo administration” Clin. Res. Proc., 1, 117 (Abstract).Google Scholar
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