Hostname: page-component-76fb5796d-x4r87 Total loading time: 0 Render date: 2024-04-25T10:49:14.761Z Has data issue: false hasContentIssue false
  • English
  • Français

Jaundice Associated with Amitriptyline

Published online by Cambridge University Press:  29 January 2018

D. H. Morgan
D. H. Morgan*
Affiliation:
Queen Elizabeth Hospital, Birmingham
Get access Rights & Permissions [Opens in a new window]

Extract

Reports of serious complications arising from the administration of amitriptyline have been very few, particularly when account is taken of the widespread prescription of this drug in recent years for depressive illness. This is a report of three cases of jaundice, one mild, one fatal, and the third severe, but leading to a good recovery, occurring following the administration of amitriptyline, though in two cases other drugs were being given concurrendy. The makers of amitriptyline do include in their literature a caution about the very occasional link with jaundice, but only two cases have so far been reported (Cunningham, 1965; Biagi and Bapat, 1967). In a recent article (Sherlock, 1968), no specific mention was made of amitriptyline in particular, or of tricyclic antidepressant drugs in general, as liable to produce hepatic disorder.

Type
Short Papers
Information
The British Journal of Psychiatry , Volume 115 , Issue 518 , January 1969 , pp. 105 - 106
Copyright
Copyright © Royal College of Psychiatrists, 1969 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abbruzzese, A., and Swanson, J. (1965). New Engl. J. Med., 273, 321.CrossRefGoogle Scholar
Blagi, R. W., and Bapat, B. N. (1967). Brit. J. Psychiat., 113, 1113–1114.Google Scholar
Cacioppo, J., and Merlis, S. (1961). Amer. J. Psychiat., 117, 1040–1041.Google Scholar
Cunningham, M. L. (1965). Brit. J. Psychiat., 111, 1107–1109.CrossRefGoogle Scholar
Hargreaves, T., and Lathe, G. H. (1964). In: Therapeutic Agents and the Liver. (Edited by McIntyre, and Sherlock, .) London: Blackwell.Google Scholar
Pickering, D. (1966). New Engl. J. Med., 274, 1449.Google Scholar
Popper, H. (1958). J. Amer. med. Ass., 168, 2235–2242.CrossRefGoogle Scholar
Sherlock, S. (1968). Brit. med. J., i, 227–229.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.