Hostname: page-component-7c8c6479df-94d59 Total loading time: 0 Render date: 2024-03-28T21:45:18.356Z Has data issue: false hasContentIssue false

A Report on a Pair of Male Monozygotic Twins Discordant for Schizophrenia

Published online by Cambridge University Press:  29 January 2018

David A. MacSweeney*
Affiliation:
Neuropsychiatric Research Unit, M.R.C. Laboratories, Carshalton and Greenbank, West Park Hospital, Epsom, Surrey. University of London

Extract

Pollin et al. (12) found that in a series of 11 monozygotic twins (MZ) discordant for schizophrenia all of the index twins weighed less at birth, 8 of the index twins were second- born and 7 out of the 11 mothers had varying thyroid pathology ‘of clinical significance’. The following report is probably the first giving details of investigations into a pair of MZ twins who were given thyroid extract during the neonatal period because of failure to make normal progress.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1970 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Balázs, R., Cocks, W. A., Eayrs, J. T., and Kovács, S. (1969). In Hormones in Development (ed. Hamburgh, M., and Barrington, E. J. W.). In press.Google Scholar
2. Balázs, R., Cocks, W. A., Eayrs, J. T., Kovács, S. and Gaitonde, M. K. (1968). ‘Factors affecting protein metabolism in the brain.’ Biochem. J., 106, 12.Google Scholar
3. Bannister, D., and Fransella, F. (1967). The Grid Test for Schizophrenic Thought Disorder, Psychological Test Publications, Barnstaple: Clarion Printers.Google Scholar
4. Coppen, Alec (1966). ‘The Marke-Nyman Temperament Scale: an English translation.’ Brit. J. med. Psychol., 39, 55–9.Google Scholar
5. Dencker, S. J. (1958). In A Follow-up Study of 128 Closed Head Injuries in Twins. Copenhagen.Google Scholar
6. Eayrs, J. T. (1966). ‘Thyroid and central nervous development.’ In The Scientific Basis of Medicine, Annual Rev. Chapter XIX, p. 317–99, London: Athlone Press.Google Scholar
7. Eayrs, J. T. (1964). ‘Effects of neonatal hyperthyroidism on maturation and learning in the rat.’ Anim. Behav., 12, 195–9.Google Scholar
8. and Holmes, R. L. (1964). ‘Effect of Neonatal hyperthyroidism on pituitary structure and function in the rat.’ J. Endocrin., 29, 7181.Google Scholar
9. Ganong, W. F. (1967). Review of Medical Physiology, Chap. 18. p. 263. California: Lange Medical Publications.Google Scholar
10. Kahane, Z., Esser, A. H., Kline, N. S., and Vester-Gaard, P. (1967). ‘Estimation of conjugated epinephrine and norepinephrine in urine.’ J. Lab. clin. Med., 69, 1042–50.Google Scholar
11. Kovács, S., Cocks, W. A., and Balázs, R. (1969). Communication prepared for 2nd meeting, Internat. Soc. for Neurochemistry, Milan.Google Scholar
12. Pollin, W., Stabenau, J. R., Mosher, L., and Tupin, J. (1966). ‘Life history differences in identical twins discordant for schizophrenia.’ Amer. J. Orthopsychiatry, 36, 492509.Google Scholar
13. Shields, J. (1967). In Recent Developmentsin Schizophrenia (ed. Coppen, A., and Walk, A.). R.M.P.A. Special Publication, Headley Brothers, Ashford, Kent.Google Scholar
14. Shields, J. (1962). In Monozygotic Twins Brought Up Apart and Brought Up Together, London: Oxford University Press.Google Scholar
15. Slater, E. (1953). ‘Psychotic neurotic illness in twins.’ Med. Res. Coun. Spec. Rept. Ser. No. 278, London: H.M.S.O.Google Scholar
16. Tanner, J. M. (1951). ‘Current advances in the study of physique.’ Lancet, i, 574–9.Google Scholar
17. Tanner, J. M. (1962). ‘Growth at Adolescence.’ Scientific Publications, Oxford: Blackwell, 176–7.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.