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Family History Studies: VII. Manic Depressive Disease Versus Depressive Disease

Published online by Cambridge University Press:  29 January 2018

Remi J. Cadoret ,
George Winokur  and
Paula J. Clayton
Remi J. Cadoret
Affiliation:
From the Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110
George Winokur
Affiliation:
From the Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110
Paula J. Clayton
Affiliation:
From the Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110
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Extract

During the past twenty years, the unity of manic-depressive disease as defined by Kraepelin (1913) has been questioned by investigators who have presented clinical and genetic evidence that the disease is heterogeneous and contains at least two discrete groups (Leonhard, 1957; Perris, 1966). In one of these groups mania occurs and patients exhibit both manic and depressive phases during the course of their illness. This group has been designated bipolar by most investigators (Leonhard, 1957; Perris, 1966). In the other group there are only episodes of depression, and this has been designated the unipolar group by some (Perris, 1966) and corresponds largely to the ‘monopolar’ group of Leonhard (1957). In this paper we shall use the term unipolar throughout to designate an affective illness in which only depression occurs.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 116 , Issue 535 , June 1970 , pp. 625 - 635
Copyright
Copyright © Royal College of Psychiatrists, 1970 

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