Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-18T16:09:59.314Z Has data issue: false hasContentIssue false

Effects of Amylobarbitone and Nitrazepam on the Electrodermogram and Other Features of Sleep

Published online by Cambridge University Press:  29 January 2018

Ijaz Haider
Affiliation:
Formerly Research Psychiatrist, Department of Psychiatry, University of Edinburgh; now Senior Registrar, Professorial Unit, Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff CF4 7XB, Wales
Ian Oswald
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF

Extract

The elctrical resistance of the palmar skin, and the naturally-occurring difference in electrical potential between the palm and the dorsal surface of the forearm show simultaneous changes in response to sudden or emotionally-laden sensory stimuli (the ‘galvanic skin response’ or GSR). Spontaneous GSRs occur during wakefulness, especially in anxiety states, but they are reduced by general relaxation and it might be supposed that they would be absent during sleep of uniform EEG appearance. However, Oswald et al. (1959) reported that this was not so and that in sleep with very high voltage slow waves (today generally called Stage 4 sleep) there could be present random spontaneous GSR activity, measured by the potential difference technique. Since these electrical phenomena cannot be related to any known stimulus, to call them galvanic skin responses is inappropriate, and they may better be termed electrodermogram (EDG) activity.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1971 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baekland, F. (1967). ‘Pentobarbital and dexamphetamine sulfate; effects on the sleep cycle in man.Psychopharmacologia (Berl.), 11, 388–96.Google Scholar
Haider, I. (1968). ‘A double-blind controlled trial of a non-barbiturate hypnotic: nitrazepam.Brit. J. Psychiat., 114, 337–43.Google Scholar
Hartmann, E. (1968a). ‘The effect of four drugs on sleep patterns in man.Psychopharmacologia (Berl.), 12, 346–53.Google Scholar
Hartmann, E. (1968b). ‘On the pharmacology of dreaming sleep (the D-state).J. nerv. ment. Dis., 146, 165–73.Google Scholar
Kales, A., Malmstrom, E. J., Scharf, M., and Rubin, R. T. (1969). ‘Psychophysiological and biochemical changes following use and withdrawal of hypnotics.’ in Sleep: Physiology and Pathology (ed. Kales, A.). Philadelphia.Google Scholar
Lanoir, J., and Killam, E. K. (1968). ‘Alteration in the sleep-wakefulness patterns by benzodiazepines in the cat.Electroenceph. clin. Neurophysiol., 25, 530–42.Google Scholar
Lehman, H. E., and Ban, T. A. (1968). “The effect of hypnotics on rapid eye movement (REM).” Int. J. clin. Pharmacol., 15, 424–7.Google Scholar
Lester, B. K., Burgh, N. R., and Dossett, R. C. (1967). ‘Nocturnal EEG-GSR profiles: the influence of presleep states.Psychophysiology, 3, 238–48.Google Scholar
Lester, B. K., Coulter, J. D., Cowden, L. C., and Williams, H. L. (1968). ‘Secobarbital and nocturnal physiological patterns.Psychopharmacologia (Berl.), 13, 275–86.Google Scholar
Lewis, S. A., and Oswald, I. (1969). ‘Overdose of tricyclic antidepressants and deductions concerning their cerebral action.Brit. J. Psychiat., 115, 1403–10.Google Scholar
Lob, H., Papy, J. J., and Gastaut, H. (1966). ‘Action du Ro-4–5360 (Mogadon) sur le sommeil nocturne.Rev. Neurol. (Paris), 115, 545–6.Google Scholar
Matthew, H., Proudfoot, A. T., Aitken, R. C. B., Raeburn, J. A., and Wright, N., (1969). ‘Nitrazepam—a safe hypnoticBrit. med. J., 3, 23–5.Google Scholar
Oswald, I. (1962). Sleeping and Waking: Physiology and Psychology. Amsterdam.Google Scholar
Oswald, I., Taylor, A. M., and Triesman, M. (1959). ‘Further studies of response to stimulation during sleep.Electroenceph. clin. Newrophysiol., 11, 840–1.Google Scholar
Oswald, I., Berger, R. J., Jaramillo, R. A., Keddie, K. M. G., Olley, P. C., and Plunkett, G. A. (1963). ‘Melancholia and barbiturates: a controlled EEG, body and eye movement study of sleep.Brit. J. Psychiat., 109, 6678.Google Scholar
Oswald, I., Berger, R. J., Jaramillo, R. A., Keddie, K. M. G., Olley, P. C., and Priest, R. G. (1965). ‘Five weeks to escape the sleeping pill habit.Brit. med. J., 2, 1093–99.Google Scholar
Rechtschaffen, A., and Kales, A. (eds.) (1968). A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington, D.C. Google Scholar
Tissot, R. (1965). ‘The effects of certain drugs on the sleep cycle in man.’ In Sleep Mechanisms (ed. Akert, K., Bally, C. and Schadé, J. P.). Amsterdam.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.