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Effects of Chlorpromazine and Trifluoperazine on the Activity of Chronic Schizophrenics

Published online by Cambridge University Press:  29 January 2018

Ivor H. Jones
Affiliation:
Department of Psychiatry, University of Melbourne, Australia

Extract

There is a widespread belief among clinicians that trifluoperazine (Tr) is more effective than chlorpromazine (Ch) in activating retarded schizophrenic patients. We examined the effect of these two drugs on the motor activity of three groups of inactive patients: A, very inactive; B, moderately inactive and C, mildly inactive. All these patients were under 60, with at least 10 years duration of illness. We excluded those with subnormality or physical illness and those who had a leucotomy. They were all sufficiently inactive to fall below the mid-point on the Venables scale (Venables, 1957), so that an increase in activity constituted an improvement. The same supervisors and raters were used throughout and attempts were made to maintain the work environment as constant as possible. The raters did not have access to their earlier scores.

Type
Abstract
Copyright
Copyright © Royal College of Psychiatrists, 1971 

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