The British Journal of Psychiatry
Relationship Between Serum Lithium Level and Clinical Response in Acute Mania Treated with Lithium
ROBERT F. PRIEN, EUGENE M. CAFFEY, C. JAMES KLETT

Abstract

In a multihospital collaborative study on the efficacy of lithium carbonate in acute mania, results were analysed in terms of serum lithium levels. It was found that there was no advantage to serum lithium levels exceeding 1.4 m.Eq./L; higher levels increased the risk of side effects without providing better clinical results. The results also showed that levels under 0.9 m.Eq./L were ineffective in treating even mildly disturbed patients. The implications of these findings are discussed.