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Haptoglobin Types in Alzheimer's Disease and Senile Dementia

Published online by Cambridge University Press:  29 January 2018

W. Op den Velde
Affiliation:
Head of the Department of Psychiatry, Valeriuskliniek, Department of Psychiatry of the Free University of Amsterdam, Valeriusplein, Amsterdam, Netherlands
F. C. Stam
Affiliation:
Head of the Department of Psychiatry, Valeriuskliniek, Department of Psychiatry of the Free University of Amsterdam, Valeriusplein, Amsterdam, Netherlands

Extract

There is much neuropathological evidence that Alzheimer's Disease and senile dementia are essentially identical disorders (Stam, 1962; McMenemey, 1963; Jamada and Mehraein, 1968; Lauter, 1970; Torvik, 1970). Family and genetic studies also give support to this opinion, for there appears to be a tendency for both senile dementia and Alzheimer's Disease towards familial aggregation (Zerbin-Rüdin, 1967; Pratt, 1970). An extensive Swedish study has given evidence that senile dementia is determined by a single autosomal dominent gene (Sjögren et al., 1952). The difference in concordance rates between identical and non-identical twins with senile dementia is in agreement with this hypothesis (Kallmann, 1956). Furthermore, a number of families in which Alzheimer's Disease is transmitted as a regularly dominant trait have been described (Pratt, 1970). For the sporadic cases of Alzheimer's disease a cumulative polygenic action has been assumed (Larsson et al., 1963). Chromosome analysis of patients with Alzheimer's Disease and senile dementia has revealed certain abnormalities (Nielsen, 1968; Bergener and Jungklaass, 1970). Wheelan (1959) found that the MNSs blood groups appear to segregate with Alzheimer's Disease: however, another investigation failed to confirm a significant linkage between blood group genes and Alzheimer's Disease (Feldman, 1969).

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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Footnotes

A synopsis of this paper was published in the June 1972 Journal.

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