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The Iowa 500: Follow-up of 225 Depressives

Published online by Cambridge University Press:  29 January 2018

George Winokur  and
James Morrison
George Winokur
Affiliation:
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52240, U.S.A.
James Morrison
Affiliation:
University of Iowa College of Medicine, Iowa City, Iowa 52240, U.S.A.
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Extract

In previous studies we have suggested that there are two types of depressive illness (4, 5). The first of these is depressive spectrum disease which has as its prototype the early-onset female depressive; the second type is pure depressive disease, the prototype of which is the late-onset male depressive. Other family studies support the differences between these two prototypes (1, 8). The early-onset females have a considerable amount of alcoholism and probably sociopathy in their male first-degree relatives. The late-onset males have an ordinary amount of these illnesses in their male relatives. In the families of early-onset females, female relatives outnumber male relatives for the presence of depressive illness; this is not seen in late-onset males, where male and female relatives have equal amounts of depressive illness.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 123 , Issue 576 , November 1973 , pp. 543 - 548
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

1 Hopkinson, G., and Ley, P. (1969). ‘A genetic study of affective disorder.’ British Journal of Psychiatry, 115, 917–922.Google Scholar
2 Medical Research Council, Report by its Clinical Committee (1969). ‘Clinical trial of the treatment of depressive illness.’ Archives of General Psychiatry, 1, 881.Google Scholar
3 Morrison, J., Clancy, J., Crowe, R., and Winokur, G. (1972). ‘The Iowa 500: diagnostic validity in mania, depression, and schizophrenia.’ Archives of General Psychiatry. 27, 457–461.Google Scholar
4 Winokur, G. (1972). ‘Types of depressive illness.’ British Journal of Psychiatry, 120, 265–266.Google Scholar
5 Winokur, G., Cadoret, R., Dorzab, J., and Baker, M. (1971). ‘Depressive disease; a genetic study.’ Archives of General Psychiatry, 25, 135–144.CrossRefGoogle Scholar
6 Morrison, J., Clancy, J., and Crowe, R. (1972). ‘The Iowa 500: a blind family history comparison in mania, depression, and schizophrenia.’ Archives of General Psychiatry. 27, 462–464.Google Scholar
7 Winokur, G., Morrison, J., Clancy, J. and Crowe, R. (1973). ‘The Iowa 500: familial and clinical findings favor two kinds of depressive illness.’ Couiprehnsive Psychiatry. In press.CrossRefGoogle Scholar
8 Woodruff, R., Guze, S., and Clayton, P. (1971). ‘Unipolar and bipolar affective disorder.’ British Journal of Psychiatry, 199, 33–8.Google Scholar
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