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Disulfiram Implant: A Controlled Trial

Published online by Cambridge University Press:  29 January 2018

C. R. Whyte  and
P. M. J. O'Brien
C. R. Whyte
Affiliation:
Lynfield Mount Hospital, Bradford 9, Yorkshire
P. M. J. O'Brien
Affiliation:
Scalebor Park Hospital, Burley-in-Wharfedale, Yorkshire
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Extract

Hald and Jacobsen (1948) introduced disulfiram as an adjunct in the treatment of alcoholism. Its usefulness has, however, been limited by the ease with which patients may discontinue medication and resume drinking. A preparation of disulfiram suitable for implantation was developed some years ago, and though its use has been mainly confined to the continent of Europe, several case reports have been published in this country (Kellam et al., 1968; Kellam, 1969). Madden and Malcolm (1972) suggest, from a follow-up study of 47 alcoholics, that implantation is followed by a period of sobriety of about six months, but they have made no comparison with a control group of patients.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 124 , Issue 578 , January 1974 , pp. 42 - 44
Copyright
Copyright © Royal College of Psychiatrists, 1974 

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References

Aharan, C. M., Ogltvie, R. D., and Partington, T. T. (1967). ‘Clinical indications of motivation in alcoholic patients.’ Quarterly Journal of Studies on Alcoholism, 28, 486–92.Google ScholarPubMed
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Malcolm, M. T., and Madden, J. S. (1973). ‘The use of disulfiram implantation in alcoholism.’ British Journal of Psychiatry, 123, 41–5.CrossRefGoogle ScholarPubMed
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