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Cerebrospinal Fluid pH and Monoamine and Glucolytic Metabolites in Alzheimer's Disease

Published online by Cambridge University Press:  29 January 2018

C. G. Gottfries ,
Åke Kjällquist ,
Urban Pontén ,
B. E. Roos  and
G. Sundbärg
C. G. Gottfries
Affiliation:
Department of Psychiatry, University Hospital, Umea, Sweden
Åke Kjällquist
Affiliation:
Department of Neurosurgery, University Hospital, Lund, Sweden
Urban Pontén
Affiliation:
Department of Neurosurgery, University Hospital, Lund, Sweden
B. E. Roos
Affiliation:
Department of Pharmacology, University of Göteborg, Sweden
G. Sundbärg
Affiliation:
Department of Neurosurgery, University Hospital, Lund, Sweden
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Extract

Determinations of acid monoamine metabolites, such as homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), in cerebrospinal fluid (CSF) give valid information on the metabolism of the corresponding amines in the brain tissue (Moir et al., 1970; Roos, 1970). The monoamine metabolites in the CSF are related to age. The concentrations of HVA and 5-HIAA increase with age (Gottfries et al., 1971). Probenecid blocks the elimination of HVA and 5-HIAA from brain tissue to blood (Neff et al., 1964, 1967; Werdinius, 1966) and from CSF to blood (Guldberg et al., 1966; Olsson and Roos, 1968). Probenecid thus normally induces an increase in the concentrations of the acid monoamine metabolites in the CSF, which is related to the turnover of monoamines in the brain tissue.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 124 , Issue 580 , March 1974 , pp. 280 - 287
Copyright
Copyright © Royal College of Psychiatrists, 1974 

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