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Serum Creatine Kinase in Acute Psychosis

Published online by Cambridge University Press:  29 January 2018

T. Harding
T. Harding*
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF
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Extract

The enzyme creatine kinase (CK) is present in high concentration in skeletal and cardíac muscle and brain tissue (Dawson and Fine, 1967). Raised serum levels of the enzyme occur in skeletal muscle disease, following myocardial infarction and in hypothyroidism. Raised levels have also been demonstrated in acute cerebral disease (Acheson et al., 1965), but earlier suggestions that this might be due to leakage of enzyme from brain tissue have not been confirmed by isoenzyme separation studies (Dubo et al., 1967), which have shown that the excess enzyme came from striated muscle. Raised serum CK levels associated with acute psychosis have also been reported (Bengzon et al., 1966; Meitzer et al., 1969; Coffey et al., 1970; and Gosling et al., 1972). This has led to the suggestion that serum CK estimation could be used in the differential diagnosis of psychiatric patients (Meltzer et al., 1970; Gosling et al., 1972). Meitzer (1969) has also claimed that the biochemical abnormality reflects ‘a basic patho-physiological process common to the acute psychoses'.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 125 , Issue 586 , September 1974 , pp. 280 - 285
Copyright
Copyright © Royal College of Psychiatrists, 1974 

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References

Acheson, J., James, D. C. Hutchison, E. C. & Westhead, R. (1965) Serum c1 eatine kinase levels in cerebral vascular disease. Lancet, i, 1306—7.Google Scholar
Bengzon, A., Hippius, H. & Kanig, K. (1966) Some changes in the serum during treatment with psychotropic drugs. Journal of Nervous and Mental Diseases, 143, 369—76.CrossRefGoogle ScholarPubMed
Coffey, J. W., Heath, R. G. & Guschwan, A. F. (1970) Serum creatine kinase, aldolase and copper in acute and chronic schizophrenics. Biological Psychiatry, 2, 331—9.Google ScholarPubMed
Dawson, D. M. & Fine, I. H. (1967) Creatine kinase in human tissues. Archives of Neurology, 16, 175—80.CrossRefGoogle ScholarPubMed
Dubo, H., Park, D. C., Pennington, R. J. T., Kalbag, R. M. & Walton, J. N. (1967) Serum creatine kinase in cases of stroke, head injury and meningitis. Lancet, ii, 743—8.Google Scholar
Gosling, R., Kerry, R. J., Orme, J. E. & Owen, G. (1972) Creatine Phosphokinase activity in newly admitted psychiatric patients. British Journal of Psychiatry, 121, 351—5.CrossRefGoogle ScholarPubMed
Griffiths, P. D. (1966) Serum levels of ATP creatine phosphotiansferase. The normal range and effect of muscular activity. Clinica Chimica Acta, 13, 413—20.CrossRefGoogle ScholarPubMed
Kupfer, D. J., Meltzer, H. Y., Watt, R. J. & Snyder, F. (1970) Serum enzyme level changes during sleep deprivation. Nature, 228, 768—70.CrossRefGoogle Scholar
Leobel, J. P. & Robins, A. H. (1973) Creatine Phosphokinase activity in psychiatric patients. British Journal of Psychiatry, 122, 617—8.Google Scholar
Meltzer, H. Y. (1969) Muscle enzyme release in acute psychosis. Archives of General Psychiatry, 21, 102—12.CrossRefGoogle Scholar
Meltzer, H. Y., Elkun, L. & Moline, R. A. (1970) Serum enzyme changes in newly admitted psychiatric patients. Archives of General Psychiatry, 21, 731—8.Google Scholar
Meltzer, H. Y., Grinspoon, L. & Shader, R. I. (1970) Serum creatine Phosphokinase and aldolase activity in acute schizophrenic patients and their relatives. Comprehensive Psychiatry, 11, 552—8.CrossRefGoogle ScholarPubMed
Rosalki, S. B. (1967) An improved procedure for serum creatine Phosphokinase estimation. Journal of Laboratory and Clinical Medicine, 69, 696—705.Google Scholar
Schiavone, D. J. & Kaldor, J. (1965) Creatine Phosphokinase levels and cerebral disease. Medical Journal of Australia, ii, 790—2.Google Scholar
Smith, A. F. (1967) Diagnostic value of serum creatine kinase in a coronary care unit. Lancet, ii, 178—82.Google Scholar
Smith, A. F., Macfie, W. G. & Oliver, M. F. (1970) Clofibrate, serum enzymes and muscle pain. British Medical Journal, ii, 86—8.Google Scholar
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