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Brom-ergocryptine in the Treatment of Phenothiazine-Induced Galactorrhoea

Published online by Cambridge University Press:  29 January 2018

P. Beumont ,
J. Bruwer ,
B. Pimstone ,
A. Vinik  and
W. Utian
P. Beumont*
Affiliation:
From the Departments of Psychiatry and Endocrinology, Groote Schuur Hospital and the University of Cape Town, and from Stikland Hospital, Cape, South Africa
J. Bruwer
Affiliation:
From the Departments of Psychiatry and Endocrinology, Groote Schuur Hospital and the University of Cape Town, and from Stikland Hospital, Cape, South Africa
B. Pimstone
Affiliation:
From the Departments of Psychiatry and Endocrinology, Groote Schuur Hospital and the University of Cape Town, and from Stikland Hospital, Cape, South Africa
A. Vinik
Affiliation:
From the Departments of Psychiatry and Endocrinology, Groote Schuur Hospital and the University of Cape Town, and from Stikland Hospital, Cape, South Africa
W. Utian
Affiliation:
From the Departments of Psychiatry and Endocrinology, Groote Schuur Hospital and the University of Cape Town, and from Stikland Hospital, Cape, South Africa
*
∗Correspondence to be addressed to Dr. P. Beumont, Department of Psychiatry, Groote Schuur Hospital, Observatory, Cape.
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Extract

An ergot alkaloid, 2-br-alpha-ergocryptine (CB 154), referred to hereafter as brom-ergocryptine, has been reported to inhibit puerperal lactation (Varga, Lutterbeck et al., 1972), and to terminate breast secretion in patients with inappropriate lactation (Lutterbeck, Pryor et al., 1971). Besser, Park et al. (1972) found that the drug suppressed elevated levels of plasma prolactin in five patients whose inappropriate lactation was due to a variety of causes. This hormonal effect was accompanied by clinical changes such as the disappearance of galactorrhoea, return of menstruation, and an increase in sexual potency.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 126 , Issue 3 , March 1975 , pp. 285 - 288
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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Footnotes

A synopsis of this paper was published in the September 1974 Journal.

This work was supported by grants from the South African Medical Research Council, and from Sandoz Ltd.

References

Besser, G. M., Parke, L., Edwards, G. R. W., Forsyth, I. A. & McNally, A. L. (1972) Galactorrhoca: successful treatment with reduction of plasma prolactin levels of brom-ergocryptine. British Medical Journal, iii, 669–72.Google Scholar
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