Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-19T15:29:34.503Z Has data issue: false hasContentIssue false
  • English
  • Français

Fertility of the Sibs of Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

Carol Buck ,
G. Edgar Hobbs ,
Helen Simpson  and
James M. Wanklin
Carol Buck
Affiliation:
Department of Epidemiology and Preventive Medicine, University of Western Ontario, London, Ontario, Canada
G. Edgar Hobbs
Affiliation:
Department of Psychiatry, University of Western Ontario, Westminster Hospital, London, Ontario, Canada
Helen Simpson
Affiliation:
Department of Epidemiology and Preventive Medicine, University of Western Ontario, London, Ontario, Canada
James M. Wanklin
Affiliation:
Department of Epidemiology and Preventive Medicine, University of Western Ontario, London, Ontario, Canada
Get access Rights & Permissions [Opens in a new window]

Summary

This investigation has provided evidence against the hypothesis that heterozygous carriers of a schizophrenic gene have a reproductive advantage through enhanced fertility. An advantage arising from lower mortality between birth and the end of the reproductive period was not investigated, but should be examined before we search for other explanations of the apparently stable polymorphism of schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 127 , Issue 3 , September 1975 , pp. 235 - 239
Copyright
Copyright © Royal College of Psychiatrists, 1975 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allison, A. C. (1954) Protection afforded by sickle-cell trait against subtertian malarial infection. British Medical Journal, i, 290–4.Google Scholar
Anthony, E. J. (1968) The developmental precursors of adult schizophrenia. In The Transmission of Schizophrenia (eds. Rosenthal, D. and Kety, S. S.). New York: Pergamon Press.Google Scholar
Böök, J. A. (1953) Schizophrenia as a gene mutation. Acta Genetica (Basel), 4, 133–9.Google ScholarPubMed
Erlenmeyer-Kimling, L., & Paradowski, W. (1966) Selection and schizophrenia. American Naturalist, 100, 651–65.CrossRefGoogle Scholar
Essen-Möller, E. (1959) Mating and fertility patterns in families with schizophrenia. Eugenics Quarterly, 6, 142–7.CrossRefGoogle Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A. Jr., Winoker, G., & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Fuller, J. L. & Thompson, W. R. (1960) Behavior Genetics. New York: John Wiley and Sons.CrossRefGoogle Scholar
Gregory, I. (1960) Genetic factors in schizophrenia. American Journal of Psychiatry, 116, 961–72.CrossRefGoogle ScholarPubMed
Heston, L. L. (1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. British Journal of Psychiatry, 112, 819–25.CrossRefGoogle ScholarPubMed
Huxley, J., Mayr, E., Osmond, H. & Hoffer, A. (1964) Schizophrenia as a genetic morphism. Nature, 204, 220–1.CrossRefGoogle ScholarPubMed
Karlsson, J. L. (1973) An Icelandic family study of schizophrenia. British Journal of Psychiatry, 123, 549–53.CrossRefGoogle ScholarPubMed
Kay, D. W. K. & Lindelius, R. (1970) A study of schizophrenia. Acta Psychiatrica Scandinavica, Suppl. 216.Google Scholar
Knudson, A. G. Jr., Wayne, L., & Hallett, W. Y. (1967) On the selective advantage of cystic fibrosis heterozygotes. American Journal of Human Genetics, 19, 338–92.Google ScholarPubMed
Kultner, R. E. & Lorincz, A. B. (1966) Schizophrenia and evolution. Eugenics Quarterly, 13, 355–6.Google Scholar
Larson, C. A. & Nyman, G. E. (1973) Differential fertility in schizophrenia. Acta Psychiatrica Scandinavica, 49, 272–80.CrossRefGoogle ScholarPubMed
Lewis, A. (1958) Fertility and mental illness. Eugenics Review, 50, 91–106.Google ScholarPubMed
Moran, P. A. P. (1972) Theoretical considerations on schizophrenic genetics. In Genetic Factors in Schizophrenia (ed. Kaplan, A. R.), p. 294. Springfield, Ill.: Thomas.Google ScholarPubMed
Penrose, L. S. (1956) Mutation in man. Acta Genetica (Basel), 6, 169–82.Google ScholarPubMed
Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorders. London: Oxford University Press.Google Scholar
Wender, P. H. (1968) The role of genetics in the etiology of schizophrenia: recent research. American Journal of Orthopsychiatry, 38, 241–3.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.