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A Comparison of Piribedil, Procyclidine and Placebo in the Control of Phenothiazine-induced Parkinsonism

Published online by Cambridge University Press:  29 January 2018

R. H. S. Mindham ,
Pauline Lamb  and
Rachel Bradley
R. H. S. Mindham
Affiliation:
University Department of Psychiatry, Mapperley Hospital, Nottingham NG3 6AA
Pauline Lamb
Affiliation:
Mapperley Hospital, Nottingham
Rachel Bradley
Affiliation:
St Ann's Hospital, Nottingham
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Summary

A double-blind, cross-over trial of the effectiveness of piribedil, procyclidine and placebo in the control of parkinsonism induced by fluphenazine decanoate was conducted in sixteen cases of chronic schizophrenia. Procyclidine was shown to be more effective and piribedil less effective than the placebo. Piribedil produced a number of unpleasant effects, including headache, vomiting and malaise.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 130 , Issue 6 , June 1977 , pp. 581 - 585
Copyright
Copyright © Royal College of Psychiatrists, 1977 

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