Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-19T10:42:00.486Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetical Analysis of Unipolar and Bipolar Endogenous Affective Psychoses

Published online by Cambridge University Press:  29 January 2018

Olga Trzebiatowska-Trzeciak
Olga Trzebiatowska-Trzeciak*
Affiliation:
Psychiatric Out-patients Department, Szamotuly, Poland
Get access Rights & Permissions [Opens in a new window]

Abstract

The mode of inheritance of affective psychoses was studied in 800 first degree and 582 second degree relatives of 122 probands. Morbidity risk for unipolar depression was 12·0±3·2 and 11·4±2·7 per cent respectively for parents and siblings of probands suffering from unipolar depression. Morbidity risk for manic-depressive psychosis for the respective groups of first degree relatives of manic-depressive probands was 15·1±3·2 and 16·9±3·2 per cent. In second degree relatives the morbidity risk was 3·4±1·0 and 5·3±1·4 per cent for unipolar depression and manic-depressive psychosis respectively.

The results indicate the role of genetical factors in the etiology of both types of affective disorder and show that unipolar depression and manic-depressive psychosis are distinct entities. The hypothesis of X-linked dominant transmission was not confirmed in either of these affective disorders. By means of the computational model of Slater, no results compatible with a polygenic inheritance of unipolar depression or manic-depressive psychosis were found.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 131 , Issue 5 , November 1977 , pp. 478 - 485
Copyright
Copyright © Royal College of Psychiatrists, 1977 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Angst, J. (1966) Zur ätiologie endogener depresiver Psychosen. Monographien aus dem Gesamtgebiete der Neurologie und Psychiatrie, p 112. Berlin-Heidelberg-New York: Springer Verlag Google Scholar
Angst, J. & Perris, C. (1972) The nosology of endogenous depression. International Journal of Mental Health, 1, 145–58.CrossRefGoogle Scholar
Breborowicz, G. & Trzebiatowska-Trzeciak, O. (1976) A method for testing differences in morbidity risk for affective psychoses. Acta Psychiatrica Scandinavica, 54, 353–8.Google Scholar
Feeve, R., Mendlewicz, J. & Fleiss, J. L. (1973) Manic-depressive illness: linkage with the Xg blood group. American Journal of Psychiatry, 130, 1355–9.Google Scholar
Gershon, E. S., Dunner, D. L. & Goodwin, F. K. (1971) Towards a biology of affective disorder. Archives of General Psychiatry, 25, 1–15.CrossRefGoogle Scholar
James, N. McI. & Chapman, C. J. (1975) A genetic study of bipolar affective disorder. British Journal of Psychiatry, 126, 429–36.CrossRefGoogle ScholarPubMed
Kraepelin, E. (1899) Lehrbuch der Psychiatrie. 6th Ed. Google Scholar
Kraepelin, E. (1921) Manic-depressive Insanity and Paranoia (translated by Barclay, M.). Edinburgh.Google Scholar
Larsson, T. & Sjögren, T. (1954) Methodological psychiatric and statistical study. Acta Psychiatrica et Neurologica Scandinavica. Supplementum 89.Google Scholar
Leonhard, K. (1959) Aufteilung der Endogenen Psychosen. Second edition. Berlin: Akademie Verlag.Google Scholar
Loranger, A. W. (1975) X-linkage and manic-depressive illness. British Journal of Psychiatry, 127, 482–8.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Fieve, R. R., Rainer, J. D. & Cataldo, M. (1973) Affective disorder of paternal and maternal sides. British Journal of Psychiatry, 122, 31–4.Google Scholar
Mendlewicz, J. & Fleiss, J. L. (1974) Linkage studies with X-chromosome markers in bipolar manic-depressive and unipolar depressive illness. Biological Psychiatry, 9, 261–94.Google Scholar
Mendlewicz, J., Fleiss, J. L. & Fieve, R. R. (1972) Evidence for X-linkage in the transmission of manic-depressive psychosis. Journal of the American Medical Association, 222, 1624–8.Google Scholar
Perris, C. (1966) A study of bipolar manic-depressive and unipolar recurrent depressive psychoses. Acta Psychiatrica Scandinavica. Supplementum 194.Google Scholar
Perris, C. (1969) Genetic transmission of depressive psychosis. Acta Psychiatrica Scandinavica. Supplementum 203.Google Scholar
Perris, C. (1971) Abnormality on paternal and maternal sides: observations in bipolar manic-depressive and unipolar depressive psychosis. British Journal of Psychiatry, 118, 207–10.CrossRefGoogle Scholar
Reich, T., Clayton, P. & Winokur, G. (1969) Family history studies: V. The genetics of mania. American Journal of Psychiatry, 125, 1358–69.CrossRefGoogle ScholarPubMed
Slater, E. (1936) The inheritance of manic-depressive insanity. Proceedings of the Royal Society of Medicine, 29, 981–90.Google ScholarPubMed
Slater, E. (1966) Expectation of abnormality on paternal and maternal sides: a computational model. Journal of Medical Genetics, 3, 159–61.Google Scholar
Slater, E., Maxwell, J. & Price, J. S. (1971) Distribution of ancestral secondary cases in bipolar affective disorders. British Journal of Psychiatry, 118, 215–18.CrossRefGoogle ScholarPubMed
Slater, E. & Tsuang, M. T. (1968) Abnormality on paternal and maternal sides: observations in schizophrenia and manic-depression. Journal of Medical Genetics, 5, 197–9.Google Scholar
Stenstedt, A. (1952) A study in manic-depressive psychosis. Acta Psychiatrica et Neurologica Scandinavica. Supplementum 79.Google Scholar
Strömgren, E. (1950) Statistical and genetical population studies within psychiatry: methods and principal results. Actualités Scientifiques et Industrielles. 1101 Congrès International de Psychiatrie, Paris, 6, 155–7.Google Scholar
Trzebiatowska-Trzeciak, O. (1975) The analysis of genetical factors in unipolar and bipolar affective psychoses. (Thesis in Polish.) Academy of Medicine, Poznan.Google Scholar
Trzebiatowska-Trzeciak, O. (1977) Clinical analysis of unipolar and bipolar endogenous affective psychoses. In preparation.CrossRefGoogle Scholar
Weinberg, W. (1925) Methoden und Technik der Statistik mit besonderer Berucksichtung der Sozialbiologie. In Handbuch der Sozialen Hygiene (eds Gottstein, A., Schlossmann, A. and Teleky, L.), Berlin, vol 1, p 71 (quoted by Stenstedt, 1952).Google Scholar
Winokur, G. (1972) Types of depressive illness. British Journal of Psychiatry, 120, 265–6.Google Scholar
Winokur, G. & Tana, V. (1969) Possible role of X-linked dominant factor in manic-depressive disease. Diseases of the Nervous System, 30, 89–93.Google ScholarPubMed
Zerbin-Rüdin, E. (1967) Endogene Psychosen. In Humangenetik (ed. Becker, P. E.), vol 5, pp 513–44. Stuttgart: Georg Thieme Verlag Google Scholar
Zerbin-Rüdin, E. (1971) Genetische Aspekte der endogenen Psychosen. Fortschritte der Neurologic und Psychiatrie, 39, 459–94.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.